Follicular development in spontaneous and stimulated cycles in women with minimal-mild endometriosis

Tahir Mahmood, T A Mahmood, Mahmood TA, I. E. Messinis, Ioannis E. Messinis, Messinis IE, Templeton A, A Templeton, Allan Templeton
British journal of obstetrics and gynaecology · 1991 · vol. 98(8) , pp. 783–788 · doi:10.1111/j.1471-0528.1991.tb13483.x · PMID:1911586 · W2010862101
Non-randomised trial OA: closed CC0 ⤵ 7 in-corpus citations
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This study compared follicular development in spontaneous and stimulated cycles of women with minimal-mild endometriosis, finding that follicular growth is not impaired by the condition.

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Abstract

OBJECTIVE: To study follicle development in women with minimal-mild endometriosis. DESIGN: In women with endometriosis a spontaneous ovulatory cycle was compared with two subsequent cycles in which either clomiphene or clomiphene and FSH were given to stimulate folliculogenesis. Spontaneous cycles in women with tubal infertility provided a comparison group. SETTING: Infertility clinic, Aberdeen Maternity Hospital. SUBJECTS: 17 women with minimal-mild endometriosis and 10 women with tubal infertility. INTERVENTIONS: The women with endometriosis were treated with 150 mg clomiphene citrate from days 2 to 6 in one cycle and in a subsequent cycle with 150 mg clomiphene citrate on days 2 to 6 plus 75 iu FSH daily thereafter. MAIN OUTCOME MEASURES: Follicular size measured daily using ultrasound. Serum FSH estimated on days 5 and 7 and then daily. RESULTS: Spontaneous follicular growth in the women with endometriosis was similar to that in the women with tubal infertility. Follicular development began earlier in cycles with clomiphene/FSH and the leading follicle reached 16 mm 2 days sooner but the rate of growth was similar whether or not either regimen of stimulation was used. CONCLUSION: Follicular growth is not impaired by minimal-mild endometriosis. Infertility with this condition cannot be explained by altered follicular growth or responsiveness.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Menstruation Ovarian Follicle Uterine Neoplasms Adult Adult Clomiphene Clomiphene Clomiphene Drug Administration Schedule Drug Administration Schedule Endometriosis Endometriosis Endometriosis Female Female Follicle Stimulating Hormone Follicle Stimulating Hormone Follicle Stimulating Hormone Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (18)

Cited by (7)

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