The use of newer progestins for contraception

Regine Sitruk-Ware, Régine Sitruk‐Ware, Anita Nath
Contraception · 2010 · vol. 82(5) , pp. 410–417 · doi:10.1016/j.contraception.2010.04.004 · PMID:20933114 · W2074610199
Review OA: closed CC0 ⤵ 18 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-09 ⓘ

This review discusses the efficacy, safety, and user acceptability of newer progestins in combined oral contraceptives and progestin-only methods for women.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

The synthetic progestins used for contraception so far are structurally related either to testosterone (estranes and gonanes) or to progesterone (pregnanes and 19-norpregnanes). Several new progestins have been designed to minimize side-effects related to androgenic, estrogenic or glucocorticoid receptor (GR) interactions. Dienogest (DNG) and drospirenone (DRSP) exhibit a partial antiandrogenic action, and DRSP has predominant anti-mineralocorticoid properties. The 19-norpregnanes include Nestorone (NES), nomegestrol acetate (NOMAc) and trimegestone (TMG), and possess a high specificity for binding to the progesterone receptor (PR) with no or little interaction with other steroid receptors. DRSP has been developed as combination oral pills with ethinyl estradiol (EE); DNG has been combined both with EE and, more recently, with estradiol valerate (E2V). NOMAc has been used as a progestin-only method and more recently combined with estradiol (E2). Nestorone is not active orally but proved to be the most active antiovulatory progestin when used parenterally. It has been developed in various formulations such as implants, vaginal rings or transdermal gel or spray. Risks and benefits of the new progestins depend upon the type of molecular structure, the type of estrogen associated in a combination and the route of administration.

My notes (saved in your browser only)

MeSH descriptors

Contraception Contraceptives, Oral, Synthetic Contraceptives, Oral, Synthetic Progesterone Congeners Progesterone Congeners Progestins Progestins Adolescent Adult Animals Contraception Contraception Contraceptive Agents, Female Contraceptive Agents, Female Contraceptive Agents, Female Contraceptive Agents, Female Contraceptive Devices, Female Contraceptive Devices, Female Contraceptives, Oral, Combined Contraceptives, Oral, Combined

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (90)

Cited by (18)

Source provenance

openalex
last seen: 2026-05-14T06:05:56.263833+00:00
pubmed
last seen: 2026-10-08T21:08:04.945943+00:00
unpaywall
last seen: 2026-10-11T06:28:45.473802+00:00
License: CC0 · commercial use OK