Progestins and Antiprogestins in Clinical Practice

1999 · W631541366
book OA: closed CC0 ⤵ 11 in-corpus citations
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This review covers the structure and action of progesterone receptors, physiological effects of progestins in the brain and breast, pharmacology of various synthetic progestins, and their clinical applications in contraception, menopause, breast diseases, and other indications, alongside antiprogestins and pharmacokinetic considerations.

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Abstract

Physiological AspectsStructure of the Progesterone Receptor and Mode of Action of Progesterone,Anne Guiochon-MantelEffects of Progesterone and Related Steroids in the Brain,Martine El-Etr, Micha?l Schumacher, and Etienne-Emile BaulieuEffects of Progestin on the Breast: Regulation of Cell Cycle Progression by Progestins,Elizabeth A. Musgrove and Robert L. SutherlandVaginal Progesterone: Direct Access to the Uterus, Physiological Hormone Replacement in Infertility and Gynecology,Dominique de Ziegler, Carlo Bulletti, and Ettore CicinelliPharmacology of Synthetic ProgestinsPharmacology of Progestins: 17 -Hydroxyprogesterone Derivatives and Progestins of the First and Second Generation,Milan Rastislav Henzl and John A. EdwardsClinical Pharmacology of Third-Generation Gestogens,Kenneth FotherbyPharmacology of New Progestogens: The 19-Norprogesterone Derivatives,R?gine Sitruk-Ware and Kalyan SundaramHybrid Progestins: The Example of Dienogest,Michael Oettel and Cornelia HolzClinical ApplicationsContraceptionProgestogens in Contraception: Third-Generation Pills,Ulysse J. GaspardLevonorgestrel-Releasing Contraceptive Implants,C. Wayne BardinProgestin-Releasing Intrauterine Devices,Tapani LuukkainenContraceptive Vaginal Rings,Donna Shoupe and Daniel R. Mishell, Jr.Progestins for Emergency Contraception,Andr? UlmannMenopauseProgestins in Hormonal Replacement Therapy and Prevention of Endometrial Disease,R?gine Sitruk-WareProgestins in Postmenopausal Women: Epidemiological Data on Relationships with Endometrial and Breast Cancer Risk,Timothy J. KeyProgestins in Hormonal Replacement Therapy and Cardiovascular Risk,R?gine Sitruk-WareBreast DiseasesControl of Estrogen's Effects by Progestins in Breast Cancer,Jorge R. PasqualiniEpidemiology and Treatment of Benign Breast Disease: Effect of Progestins on Breast Disease,R?gine Sitruk-Ware and Genevi?ve Plu-BureauOther IndicationsTherapeutic Use of Progestins: Practical Recommendations,R?gine Sitruk-WareMetabolic Effects of ProgestinsThe Effect of Progestins on Plasma Lipids,Matti J. TikkanenHormonal Replacement Therapy and Glucose Metabolism in Postmenopausal Women,Sven O. SkoubyAntiprogestinsAntiprogestins in Clinical Practice,Irving M. Spitz and Ann RobbinsPharmacokineticsPharmacokinetics of Progesterone Administered Orally and Parenterally,Frank Z. Stanczyk

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