A Novel perception on the Genetic and Epigenetic Aspects of Endometriosis

In: Chettinad Health City Medical Journal · 2020 · vol. 9(4) · doi:10.36503/chcmj9(4)-08 · W4233332528
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This review discusses recent findings regarding the genetic and epigenetic factors, including gene loci, mRNA levels, miRNA expression, and methylation/acetylation profiles, implicated in the pathogenesis of endometriosis.

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Abstract

Endometriosis is a complex gynaecological disease mostly a ecting women of reproductive age (25 to 35 years) in 10% of the world population.Various theories have described the pathogenesis of endometriosis.Amongst them, the genetic/epigenetic theory explains nearly all observations of endometriosis.So-far several genetic loci were analyzed for their potential role in the pathogenesis of endometriosis, and some were proven to be pathologically signi cant.Other than the genes, the epigenetic modi cations such as mRNA levels, miRNA expression, methylation and acetylation pro les were also being analyzed for their potent role in endometriosis.This review is aimed at discussing the recent developments in the genetic and epigenetic aspects of endometriosis as a disease condition.

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Condition tags

endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (19)

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