Radikalitat der operativen Therapie bei Endometriose

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Surgical resection for endometriosis can improve pregnancy rates and pain, but risks complications and reduced ovarian reserve, necessitating individualized treatment decisions.

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This paper reviews current literature on indications and surgical approach for endometriosis resection, discussing how operative “radicality” should vary with disease severity and patient factors. It reports that surgical resection in many cases improves pregnancy rates and reduces pain, but notes important caveats: deep infiltrating disease surgery can cause major complications including bladder and bowel dysfunction, anastomotic insufficiency, and pain syndromes, and ovarian endometrioma surgery leads to loss of oocyte reserve. The authors argue that radicality may need restriction when both uterosacral ligaments are affected to preserve bladder function, and similarly when aiming for future pregnancy in cases of deep infiltrating endometriosis near/at the uterus or with recurrent ovarian involvement. This paper is centrally about endometriosis — it specifically discusses how the degree of radical surgical treatment should be tailored to deep infiltrating endometriosis and related risks.

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Abstract

Background Endometriosis is a common disease of adult women which can cause pain and infertility and may lead to deterioration of organs. One treatment option is surgical resection. Aim In view of the current literature, the indications for surgical resection and the procedure based on the severity of the endometriosis are discussed.

Results

Surgical resection leads in many cases to increased pregnancy rates and decreased pain. These operations can also be associated with major complications such as bowel and bladder dysfunction and insufficiency of anastomosis. Operation of ovarian endometriomas causes loss of oocytes; therefore, the indication for surgery should be very carefully considered taking advantages and disadvantages into account as well as the psychological strain and age of the patient. When both uterosacral ligaments are affected, radical treatment should be limited in order to maintain bladder function. The same should be done when there is a desire to become pregnant and deep endometriosis is found near/at the uterus or recurrent at the ovaries. Nevertheless, radical resection has its value in therapy of deep-infiltrating endometriosis because it leads to the lowest recurrence rates and there is data that it increases pregnancy rates. Complete multivisceral resection must be planned and performed by an interdisciplinary team of gynaecologists, visceral surgeons, and urologists.

Conclusion

The indication for surgery should be carefully considered taking advantages and disadvantages into account. It depends on the individual situation of the patient. In every case, the extent of treatment must be extensively discussed with the patient and an individualized treatment goal planned. Similar content being viewed by others Literatur Abrão MS et al (2015) Deep endometriosis infiltrating the recto-sigmoid: critical factors to consider before management. Hum Reprod Update 21(3):329–339 Ajonuma LC, Ng EH, Chan HC (2002) New insights into the mechanisms underlying hydrosalpinx fluid formation and its adverse effect on IVF outcome. Hum Reprod Update 8(3):255–264 Burkhardt M, Kühn T (2014) Endometriose in der Adoleszenz. Korasion 29(2):26–32 Centini G et al (2015) The impact of laparoscopic surgical management of deep endometriosis on pregnancy rate. J Minim Invasive Gynecol (im Druck). doi:10.1016/j.jmig.2015.09.015 Chapron C, Pietin-Vialle C, Borghese B, Davy C, Foulot H, Chopin N (2009) Associated ovarian endometrioma is a marker for greater severity of deeply infiltrating endometriosis. Fertil Steril 92(2):453–457 Chiang HJ et al (2015) The impact of previous ovarian surgery on ovarian reserve in patients with endometriosis. BMC Womens Health 15:74 Hart RJ et al (2008) Excisional surgery versus ablative surgery for ovarian endometriomata. Cochrane Database Syst Rev (2):CD004992. doi:10.1002/14651858.CD004992.pub3 Healey M et al (2010) Surgical treatment of endometriosis: a prospective randomized double-blinded trial comparing excision and ablation. Fertil Steril 94:2536–2540 Johnson NP et al (2002) Laparoscopic salpingectomy for women with hydrosalpinges enhances the success of IVF: a Cochrane review. Hum Reprod 17(3):543–548 Johnson N, van Voorst S, Sowter MC, Strandell A, Mol BW (2010) Surgical treatment for tubal disease in women due to undergo in vitro fertilization. Cochrane Database Syst Rev (1):CD002125. doi:10.1002/14651858.CD002125.pub3 Keckstein J et al (2003) Die laparoskopische Therapie der Darmendometriose und der Stellenwert der medikamentösen Therapie. Zentralbl Gynäkol 125:259–266 Nesbitt-Hawes EM et al (2015) The surgical treatment of severe endometriosis positively affects the chance of natural or assisted pregnancy postoperatively. Biomed Res Int 2015:438790 Osada H et al (2011) Surgical procedure to conserve the uterus for future pregnancy in patients suffering from massive adenomyosis. Reprod Biomed Online 22(1):94–99 Roman H et al (2015) Deep shaving and transanal disc excision in large endometriosis of mid and lower rectum: the Rouen technique. Surg Endosc (im Druck). doi:10.1007/s00464-015-4528-8 Roman H et al (2015) Full-thickness disc excision in deep endometriotic nodules of the rectum: a prospective cohort. Dis Colon Rectum 58(10):957–966 Sanchez AM et al (2015) Endometriosis as a detrimental condition for granulosa cell steroidogenesis and development: from molecular alterations to clinical impact. J Steroid Biochem Mol Biol 155(Pt A):35–46 Strandell A et al (2001) Hydrosalpinx and IVF outcome: cumulative results after salpingectomy in a randomized controlled trial. Hum Reprod 16:2403–2410 Ulrich U, Buchweitz O, Greb R, Keckstein J, von Leffern I, Oppelt P, Renner SP, Sillem M, Stummvoll W, De Wilde RL, Schweppe KW (2014) German and Austrian Societies for Obstetrics and Gynecology National German Guideline (S2k): guideline for the diagnosis and treatment of endometriosis: long version – AWMF Registry No. 015-045. Geburtshilfe Frauenheilkd 74(12):1104–1118 Vignali M et al (2015) Surgical excision of ovarian endometriomas: does it truly impair ovarian reserve? Long term anti-Müllerian hormone (AMH) changes after surgery. J Obstet Gynaecol Res 41(11):1773–1778 Author information Authors and Affiliations Corresponding author Ethics declarations Interessenkonflikt M. Burkhardt und S.P. Renner geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren. Additional information Redaktion W. Küpker, Baden-Baden Electronic Supplementary Material Rights and permissions About this article Cite this article Burkhardt, M., Renner, S.P. Radikalität der operativen Therapie bei Endometriose. Gynäkologische Endokrinologie 14, 15–20 (2016). https://doi.org/10.1007/s10304-015-0048-9 Published: Issue date: DOI: https://doi.org/10.1007/s10304-015-0048-9 Schlüsselwörter - Ovarielle Endometriose - Peritoneale Endometriose - Tief infiltrierende Endometriose - Interdisziplinäre Behandlung - Schwangerschaft

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