[Laparoscopic therapy of intestinal endometriosis and the ranking of drug treatment]

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Laparoscopic surgery effectively resected intestinal endometriosis in 142 patients, significantly reducing symptoms with minimal complications, while hormonal therapy is reserved for mild cases.

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This paper describes laparoscopic surgical management for severe bowel endometriosis, particularly lesions involving the rectovaginal septum and bowel (rectosigmoid and cecum with adherent bowel loops), assessing outcomes in 142 patients treated between 3/1996 and 7/2003 using approaches including full-thickness resection, stapler-assisted resections, and laparoscopic-assisted hand-sewn anastomosis. Postoperative symptom reduction was reported as 88% for defecation problems, 87% for dyspareunia, 96% for chronic pelvic pain, and 75% for sexual difficulties, with a low complication rate including anastomotic leakage (2.8%) and abscesses (1.4%). The authors also outline a role for hormonal therapy mainly for patients with minimal symptoms, and note postoperative hormonal management in cases of incomplete surgery or suspected severe adenomyosis with infertility. This paper is centrally about endometriosis — specifically laparoscopic treatment of intestinal (deep infiltrating) endometriosis with bowel involvement and the comparative role of drug therapy, including mention of adenomyosis in postoperative/infertility contexts.

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Abstract

UNLABELLED: Patients with severe endometriosis involving the rectovaginal septum and bowel makes surgery necessary. The laparoscopic approach offers the possibility to perform the complete resection with minimal invasive techniques. Small lesions can be removed by full-thickness-resection. Large nodules make a segmental resection necessary. Deep lesions are resected with stapling devices. Nodules in the sigmoid ore removed by laparoscopic assisted hand-sewn anastomosis. RESULTS: Between 3/96 and 7/03 142 patients with severe endometriosis involving the bowel have been treated laparoscopically. The pre-operative complains have been reduced as following: dyschezio: 88%, dyspareunia 87%, chronic pelvic pain 96%, disturbance of sexuality 75%. The complication rate was minimal: leakage of the anastomosis n=4 (2.8%), paraproctial abscess 2 (1.4%), blood transfusion 1 (0,7 %), severe stenosis of the anastomosis 6 (4.2%). CONCLUSION: Laparoscopic approach is a safe and effective technique to treat deep infiltrating endometriosis with bowel involvement. The hormonal treatment of bowel endometriosis is used in patients with minimal symptoms. The postoperative treatment becomes necessary in incomplete operations or in patients with severe adenomyosis and infertility.
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Abstract

Patients with severe endometriosis involving the rectovaginal septum and bowel makes surgery necessary. The laparoscopic approach offers the possibility to perform the complete resection with minimal invasiv techniques. Small lesions can be removed by full-thickness-resection. Large nodules make a segmental resection necessary. Deep lesions are resected with stapling devices. Nodules in the sigmoid ore removed by laparoscopic assisted hand-sewn anastomosis.

Results

Between 3/96 and 7/03 142 patients with severe endometriosis involving the bowel have been treated laparoscopically. The pre-operative complains have been reduced as following: dyschezio: 88 %, dyspareunia 87 %, chronic pelvic pain 96 %, disturbance of sexuality 75 %. The complication rate was minimal: leakage of the anastomosis n=4 (2,8 %), paraproctial abscess 2 (1,4 %), blood transfusion 1 (0,7 %), severe stenosis of the anastomosis 6 (4,2 %).

Conclusion

Laparoscopic approach is a safe and effective technique to treat deep infiltrating endometriosis with bowel involvement. The hormonal treatment of bowel endometriosis is used in patients with minimal symptoms. The postoperative treatment becomes necessary in incomplete operations or in patients with severe adenomyosis and infertility. Schlüsselwörter Darmendometriose - laparoskopische Resektion - Langzeit-Follow-up - medikamentöse Therapie Key words Bowel endometriosis - laparoscopic treatment - longtime follow-up - hormonal treatment Literatur - 1 Bailey H R, Ott M T, Hartendorp P. Aggressive surgical management for advanced colorectal endometriosis. Dis Colon Rectum. 1994; 37 747-753 - 2 Busacca M, Bianchi S, Agnoli B, Candiani M, Calia C, De Marinis S, Vignali M. Follow-up of laparoscopic treatment of stage III-IV endometriosis. J Am Assoc Gynecol Laparosc. 1999; 6 55-58 - 3 Chapron C, Dubuisson J B, Tardif D, Decoret E. Retroperitoneal endometriosis infiltrating the utero-sacral ligaments. Technique and results of laparoscopic surgery. J Gynecol Obstet Biol Reprod. 1997; 26 264-269 - 4 Donnez J, Nisolle M. Advanced laparoscopic surgery for the removal of rectovaginal septum endometriotic or adenomyotic nodules. Baillieres Clin Obstet Gynaecol. 1995; 9 769-774 - 5 Donnez J, Nisolle M, Gillerot S, Smets M, Bassil S, Casanas-Roux F. Rectovaginal septum adenomyotic nodules: a series of 500 cases. Br J Obstet Gynaecol. 1997; 104 1014-1018 - 6 Egger H, Turnwald W, Weiß S. Radikale operative Behandlung der Endometriose mit Darmteilresektion. Geburtshilfe Frauenheilkunde. 1998; 58 415-419 - 7 Garry R, Clayton R, Hawe J. The effect of endometriosis and ist radical laparoscopic excision on quality of life indicators. BJOG. 2000; 107 44-54 - 8 Gordon S J, Maher P J, Woods R. Use of the CEEA stapler to avoid ultra-low segmental resection of a full-thickness rectal andometriotic nodule. J Am Assoc Gynecol Laparosc. 2001; 8 312-316 - 9 Jerby B L, Kessler H, Falcone T, Milsom J W. Laparoscopic management of colorectal endometriosis. Surg Endosc. 1999; 13 1125-1128 - 10 Keckstein J. Die chirurgische Therapie der Endometriose. WMW. 1999; 13 366-371 - 11 Keckstein J. Laparoskopische Lasertherapie der Endometriose. Gynäkologe. 1993; 26 317-325 - 12 Keckstein J, Hucke J. Die endoskopischen Operationen in der Gynäkologie. Urban & Fischer, Mü nchen 2000 - 13 Keckstein J, Schweppe K, Possover M, Neis K. et al .Enzian: Eine neue Klassifikation der tiefen Endometriose. Konsensustreffen: Stiftung Endometriose Forschung, Neusach 2002; Publikation in Vorbereitung - 14 Keckstein J, Tuttlies F. Die laparoskopische Therapie der Endometriose. Der Gynäkologe. 1997; 30 473-482 - 15 Keckstein J, Wiesinger H, Kandolf O. Laparoscopic bowel resection in severe endometriosis in 35 patients. Meeting of the European Society of Gynecological Endoscopy 1999 - 16 Koninckx P R, Martin D. Treatment of deeply infiltrating endometriosis. Curr Opinion Obstet and Gynecol. 1994; 6 231-241 - 17 Koninckx P R, Meuleman C, Demeyere S, Lesaffre E, Cornillie F J. Suggestive evidence that pelvic endometriosis is a progressive disease, whereas deeply infiltrating endometriosis is associated with pelvic pain. Fertil Steril. 1991; 56 590-591 - 18 Koninckx P R, Timmermans B, Meuleman C, Penninckx F. Complications of CO2-Laser endoscopic excision of deep endometriosis. Hum Reprod. 1996; 11 2263-2268 - 19 Maher P, Wood C, Hill D. Excision of endometriosis in the pouch of Douglas by combined laparovaginal surgery using the Maher abdominal elevator. J Am Assoc Gynecol Laparosc. 1995; 2 199-202 - 20 Nezhat F, Nezhat C, Pennington E, Ambroze W. Laparoscopic segmental resection for infiltrating endometriosis of the rectosigmoid colon: a preliminary report. Surg Laparosc Endosc. 1992; 2 212-216 - 21 Nezhat C, Nezhat F, Pennington E, Nezhat C H, Ambroze W. Laparoscopic disk excision and primary repair of the anterior rectal wall for the treatment of full-thickness bowel endometriosis. Surg Endosc. 1994; 8 682-685 - 22 Nezhat C, Pennington E, Nezhat F, Silfen S L. Laparoscopically assisted anterior rectal wall resection and reanastomosis for deeply infiltrating endometriosis. Surg Laparosc Endosc. 1991; 1 106-108 - 23 Possover M, Diebolder H, Plaul K, Schneider A. Laparascopically assisted vaginal resection of rectovaginal endometriosis. Obstet Gynecol. 2000; 96 304-307 - 24 Redwine D, Sharpe D R. Laparoscopic segmental resection of the sigmoid colon for endometriosis. Laparoendosc Surg. 1991; 1 217-220 - 25 Redwine D, Wright J. Laparoscopic treatment of complete obliteration of the cul-d with endometriosis: long-term follow-up of en bloc resection. Fertil Steril. 2001; 76 358-365 - 26 Sharpe D R, Redwine D B. Laparoscopic segmental resection of the sigmoid and rectosigmoid colon for endometriosis. Surg Laparosc Endosc. 1992; 2 120-124 Dr. Prim. Univ.-Prof. Jörg Keckstein Landeskrankenhaus Villach Abtlg. für Gynäkologie und Geburtshilfe Nikolaigasse 43 9500 Villach Phone: 0 42 42-2 08-23 92 Fax: 0 42 42-2 08-23 07 Email: [email protected]

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Condition tags

endometriosisadenomyosisdie_deep_infiltratingbowel_endometriosischronic_pelvic_paindyspareuniainfertility

MeSH descriptors

Endometriosis Endometriosis Gynecologic Surgical Procedures Laparoscopy Endometriosis Endometriosis Female Gynecologic Surgical Procedures Gynecologic Surgical Procedures Humans Laparoscopy Laparoscopy Postoperative Complications Postoperative Complications Postoperative Pain Postoperative Pain Pregnancy Rectal Diseases Rectal Diseases Rectal Diseases

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