Fertility and sterility

OBJECTIVE: To analyze the expression of the glycodelin gene to better understand the molecular environment of endometriotic lesions and to elucidate the potential mechanisms that underlie the complex physiopathology of endometriosis. DESIG…

OBJECTIVE: HOXA10 is an essential regulator of endometrial receptivity. To determine the effect of GnRH antagonists on endometrial receptivity, we assessed endometrial HOXA10 expression in GnRH antagonist, GnRH agonist, and natural cycles. …

OBJECTIVE: To evaluate gonadotropin-releasing hormone (GnRH) agonist/antagonist conversion with estrogen priming (AACEP) in low responders with prior IVF failure. DESIGN: Descriptive. SETTING: Private practice. PATIENT(S): Women aged <or…

OBJECTIVE: To determine the prevalence of histologically proven endometriosis in a subset of infertile women. DESIGN: Retrospective case series with electronic file search and multivariable logistic regression analysis. SETTING: Tertiary …

OBJECTIVE: To compare the expression of human leukocyte antigen-G (HLA-G) in endometrial samples from patients with and without adenomyosis. DESIGN: Laboratory study using human tissue. SETTING: University hospital. PATIENT(S): Thirty-fo…

OBJECTIVE: To report a case of complete obstructing uterine septum repaired in a minimally invasive manner by operative hysteroscopy under laparoscopic guidance. A complete obstructing uterine septum is a rare congenital abnormality. To dat…

OBJECTIVE: To report a case of monozygotic twins with unilateral ovarian tumors of different histology and character. DESIGN: Case report. SETTING: Medical center and teaching hospital. PATIENT(S): A 22-year-old woman with ruptured ovari…

OBJECTIVE: To evaluate the levels of interleukin-1beta (IL1beta) and its inhibitory soluble interleukin-1 receptor type II (IL1R2) in the peritoneal fluid (PF) of normal women and patients with endometriosis suffering from pelvic pain and i…

OBJECTIVE: To analyze the influence of postoperative GnRH agonist treatment on disease recurrence after conservative laparoscopic surgery for ovarian endometriomas according to duration of the treatment. DESIGN: Retrospective cohort study.…

OBJECTIVE: To investigate cell invasiveness and the production of matrix metalloproteinase-2 (MMP-2), MMP-9, tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2 in endometrial stromal cells (ESCs) of adenomyosis. DESIGN: Prospectiv…

OBJECTIVE: To determine whether a mixed population of immortalized human endometriosis epithelial and stromal cells is able to induce peritoneal endometriosis in nude mice. DESIGN: Prospective experimental study. Human immortalized endomet…

OBJECTIVE: To investigate the effects of selective cyclooxygenase-2 (COX-2) inhibition on the ovarian hyperstimulation syndrome (OHSS) in an experimental model. DESIGN: Controlled laboratory study. SETTING: University-affiliated fertility…

OBJECTIVE: To determine whether high levels of interleukin (IL)-10 can attenuate the production of tumor necrosis factor (TNF)-alpha-induced proinflammatory cytokines in endometriotic stromal cells. DESIGN: Prospective study. SETTING: Dep…

OBJECTIVE: To evaluate interleukin (IL)-12 and IL-18 levels in the serum and peritoneal fluid of women with and without endometriosis. DESIGN: Cross-sectional survey. SETTING: University hospital. PATIENTS: Interleukin-12 and IL-18 level…

OBJECTIVE: To evaluate the association of intron 1 and exon 1 polymorphisms in the estrogen receptor alpha gene (ER-alpha) with endometriosis in women. DESIGN: Association study. SETTING: Endometriosis Unit, Federal University of São Paul…

OBJECTIVE: To investigate the involvement of the nuclear factor (NF)-kappaB in the interleukin (IL)-1 beta-mediated macrophage migration inhibitory factor (MIF) gene activation. DESIGN: Prospective study. SETTING: Human reproduction resea…

OBJECTIVE: To further investigate peritoneal iron disruption in endometriosis by studying iron storage in peritoneal macrophages of patients with endometriosis compared with controls. DESIGN: Cross-sectional study. SETTING: Academic gynec…

OBJECTIVE: To report the impact of the laparoscopic approach to the pelvic nerves in the management of neural pelvic pain in women secondary to pelvic surgery. DESIGN: Clinical prospective study. SETTING: Department of Gynecology and Obst…

OBJECTIVE: To evaluate prospectively the efficacy of laparoscopic ureterolysis versus ureteroureterostomy in women with ureteral endometriosis. DESIGN: Prospective study. SETTING: Department of Obstetrics and Gynecology, Ospedale Sacro Cu…

We report laparoscopic observation of spontaneous human ovulation, illustrated by protrusion of the mature follicle and oocyte release into the peritoneal cavity.

OBJECTIVE: To evaluate the cost effectiveness of laparoscopy for unexplained infertility. DESIGN: We performed a cost-effectiveness analysis using a computer-generated decision analysis tree. Data used to construct the mathematical model w…

OBJECTIVE: To identify possible sources of heterogeneities in the estimation of the proportion of bilateral cases and of left-sided cases of endometriotic lesions. DESIGN: We included 20 studies that reported estimated proportions, and exa…

OBJECTIVE: To investigate the protective effect of L-carnitine (LC) against deleterious substances present in the peritoneal fluid (PF) of patients with endometriosis, which may affect the oocyte cytoskeleton and embryogenesis. DESIGN: Exp…

OBJECTIVE: To determine if attempts to maximize oocyte yield during ovarian stimulation translates into improved outcome of in vitro fertilization (IVF) cycles. DESIGN: Retrospective study. SETTING: Academic tertiary care IVF center. PAT…