OBJECTIVE: To compare the efficacy and safety of dienogest (DNG) with intranasal buserelin acetate (BA) in patients with endometriosis. DESIGN: Phase III, randomized, double-blind, multicenter, controlled trial. SETTING: Twenty-four study…
OBJECTIVE: To evaluate the concentration and distribution pattern of interleukin-6-producing cells in ectopic and eutopic endometrium. DESIGN: Collection of both tissues at the proliferative cycle phase. SETTING: A university endocrinolog…
Laboratory and population-based studies suggest that exposure to environmental toxicants may be one of several triggers for the development of endometriosis. We discuss evidence that modulation of the endometrial endocrine-immune interface …
OBJECTIVE: To study the expression of leukemia inhibitory factor (LIF), its receptors LIFR and gp130, and its inhibitor SOCS1 in endometria from fertile women and infertile women with unexplained infertility. Signaling through the LIF pathw…
OBJECTIVE: To assess the effect of surgeon's increasing experience in conservative laparoscopic surgery of women with rectovaginal endometriosis on the surgical outcome of these patients recurrence rate. DESIGN: Prospective cohort study. …
OBJECTIVE: To evaluate the effectiveness of transvaginal ultrasound aspiration and ethanol sclerotherapy in patients with recurrent ovarian endometriomas. DESIGN: Retrospective study. SETTING: Teaching hospital affiliated with Chang Gung …
OBJECTIVE: To investigate how progestogens and combined oral contraceptives change nerve fiber density in peritoneal endometriotic lesions and to identify the types of nerve fibers still present during hormone treatment. DESIGN: Laboratory…
OBJECTIVE: To evaluate the effect of protein kinase C inhibition on surgically induced endometriosis in mice. DESIGN: Prospective, randomized study. SETTING: Academic facility. ANIMALS: Sixty adult female C57BJ6 mice. INTERVENTION(S): O…
OBJECTIVE: To investigate how hormonal treatment can change nerve fiber density and to identify types of nerve fibers in endometrium and myometrium in women with endometriosis. DESIGN: Laboratory study using human tissue. SETTING: Univers…
OBJECTIVE: To evaluate the clinical efficacy and patient satisfaction of danazol delivered vaginally as treatment for young women with menorrhagia. DESIGN: Prospective study. SETTING: University of Siena, Siena, Italy. PATIENT(S): Women …
OBJECTIVE: To study ghrelin concentrations in the peritoneal fluid of women with endometriosis and of control women without pelvic pathology and its associations with the levels of proinflammatory cytokines and vascular endothelial growth f…
OBJECTIVE: To present an endometrial osseous metaplasia case and reemphasize that the condition is a cause of secondary infertility. DESIGN: Case report. SETTING: Department of Obstetrics and Gynecology in a university hospital in Turkey.…
The authors evaluated the risk of developing a pelvic abscess in a series of 214 in vitro fertilization cycles that were performed in women with endometriomas. This complication was never recorded, indicating that its risk is very low (0.0;…
OBJECTIVE: To verify whether bladder and ureter endometriosis had the same clinical features and disease behavior. DESIGN: Case-control study. SETTING: Multidisciplinary group in Sao Paulo, Brazil. PATIENT(S): A total of 690 patients wer…
OBJECTIVE: To review the evidence on exposure to environmental contaminants and immune system disruption, and how this has been demonstrated or hypothesized to impact reproductive health and fertility. DESIGN: Review of literature. RESULT…
OBJECTIVE: To investigate the relationship between oxidative stress and the underlying causes of infertility, preovulatory ovarian hormones, and ovarian response to gonadotropin stimulation in patients undergoing assisted reproductive techn…
The minimum distance between the vaginal mucosal epithelium and the endometriotic glands was <1,000 microm in 30 patients (49.2%), <2,000 microm in 44 patients (72.1%), and <5,000 microm in 60 patients (98.4%). Our findings provided histolo…
OBJECTIVE: To investigate the role of catechol-O-methyl transferase (COMT) in the regulation of estrogen metabolism in human endometrium. DESIGN: Laboratory study. SETTING: Academic research laboratory. INTERVENTION(S): Immunohistochemis…
OBJECTIVE: To investigate temporal and spatial relationships of vascular endothelial growth factor (VEGF)-A and its receptor (VEGFR-1) expression in a luteal endometrium obtained from patients with repeated IVF failure. DESIGN: Immunohisto…
OBJECTIVE: To investigate the feasibility of laparoscopic high-intensity focused ultrasound (HIFU) ablation in the treatment of patients with uterine localized adenomyosis. DESIGN: A prospective clinical trial. SETTING: University teachin…
OBJECTIVE: To evaluate the possible role of endocrine-disrupting compounds (EDCs) on female reproductive disorders emphasizing developmental plasticity and the complexity of endocrine-dependent ontogeny of reproductive organs. Declining con…
Ovarian tissue inadvertently excised along with endometriomas was associated with the presence of pericystic fibrosis and serum levels of CA-125, representing the only clinical parameter for predicting follicle loss before surgery. A consec…
OBJECTIVE: To determine follicular-fluid neurotrophin levels in women undergoing assisted reproductive techniques for different etiologies of infertility. DESIGN: Prospective observational study. SETTING: Academically affiliated assisted …