Fertility and sterility

OBJECTIVE: To investigate the effects of pentoxifylline, on vascular endothelial growth factor (VEGF)-C and flk-1 expression in the rat endometriosis model. DESIGN: Prospective, randomized, placebo-controlled study. SETTING: Academic inst…

OBJECTIVE: To evaluate the effects of metoclopramide-induced hyperprolactinemia on the prolactin receptor of murine endometrium. DESIGN: Experimental study using the RNA extraction to detect tissue prolactin receptor isoforms by reverse-tr…

OBJECTIVE: To investigate the effects of testosterone and metformin on glucose metabolism in endometrium. DESIGN: In vitro experiment. SETTING: Reproductive and Genetic Center, Obstetrics and Gynecology, The First Hospital of Peking Unive…

OBJECTIVE: To compare the efficacy of recombinant human FSH (rhFSH) with rhFSH with four additional O-linked carbohydrates (rhFSH-CTP), rhFSH with four additional N-linked carbohydrates (rhFSH-N4), and the current gold standard for rodent o…

OBJECTIVE: To examine the expression of gremlin-1 (GREM1) on the levels of messenger RNA (mRNA) and protein in eutopic endometrium and its serum level in patients with endometriosis. DESIGN: Prospective, experimental study using reverse-tr…

OBJECTIVE: To examine whether thin endometria can be improved by increasing uterine radial artery (uRA) blood flow. DESIGN: A prospective observational study. SETTING: University hospital and city general hospital. PATIENT(S): Sixty-one …

To determine whether nerve fibers in the functional layer endometrium are caused by an endometriosis itself or a common symptom of pain, endometrial tissues from 30 women with endometriosis, 40 women with adenomyosis, 41 women with uterine …

In patients with endometriosis of the appendix, other sites are use to be affected by the disease, mainly bladder, rectosigmoid and retrocervical endometriosis. When these characteristics are present or if patients have more than three site…

A 26-year-old patient underwent pelvic lymphadenectomy and trachelectomy because of cervical cancer stage IB. Later she developed symptoms from obturator nerve entrapment. Examinations could not reveal metastatic cancer disease, but endomet…

OBJECTIVE: To develop a clinical tool that predicts pregnancy rates (PRs) in patients with surgically documented endometriosis who attempt non-IVF conception. DESIGN: Prospective data collection on 579 patients and comprehensive statistica…

OBJECTIVE: To present two cases of endometriosis in patients with Glanzmann's thrombasthenia (GT) and discuss the underlying pathophysiology of endometriosis. DESIGN: Case report. SETTING: Gynecology practice in a university teaching hosp…

Spontaneous hemoperitoneum in pregnancy (SHiP) is a rare but dramatic cause of perinatal mortality and morbidity. Emerging evidence suggests that pelvic endometriosis may play an important role in the pathogenesis of SHiP.

OBJECTIVE: To document a rare case of endometriosis in the soleus and gastrocnemius muscles. DESIGN: Case report. SETTING: Tertiary care center. PATIENT(S): A 30-year-old fertile woman presented with moderate dysmenorrhea associated with…

Examination of 631 infertile women, including 434 women with endometriosis and 197 without endometriosis, revealed an increasing incidence of endometrial polyps, especially in the test subjects with endometriosis, and advanced stages of end…

OBJECTIVE: To evaluate the roles of endometrial matrix metalloproteinase (MMP)-2 and -9, vascular endothelial growth factors (VEGF), and microvascular density (MVD) in the occurrence of anovulatory dysfunctional uterine bleeding (DUB). DES…

Primary human uterine, cervical, and ectocervical stromal fibroblasts constitutively secrete hepatocyte growth factor (HGF), yet only uterine stromal fibroblasts increase HGF secretion in response to estradiol. Estradiol-induced HGF secreti…

OBJECTIVE: To analyze the expression of estrogen (ER) and progesterone (PR) receptors in the smooth muscle component (SMC) of deep infiltrating endometriosis (DIE). DESIGN: A prospective clinical and pathologic study of 60 cases of DIE. S…

OBJECTIVE: To investigate the eutopic endometrial interleukin-18 (IL-18) system including interleukin-18 (IL-18), IL-18 receptor (IL-18R), and IL-18 binding protein (IL-18BP), mRNA, and protein expression in patients with adenomyosis. DESI…

OBJECTIVE: To determine possible involvement of splice variant 1 (SV1), a variant of the pituitary growth hormone-releasing hormone (GHRH) receptor, in the development of endometriosis. DESIGN: Comparative and laboratory study. SETTING: U…

OBJECTIVE: To investigate the expression of interleukin-10 (IL-10) in adenomyosis. DESIGN: Laboratory study using human tissue. SETTING: University hospital. PATIENT(S): Thirty-four patients with adenomyosis and 30 women without adenomyo…

OBJECTIVE: To investigate the expression and localization of interleukin-8 (IL-8) and monocyte chemotactic protein 1 (MCP-1) in women with and without endometriosis. DESIGN: Comparative immunohistochemical study. SETTING: Academic medical…

Fenofibrate -a peroxisome proliferator-activated receptor-a agonist- is an angiostatic agent that is commonly used in human liver diseases, therefore it may interfere with the angiogenetic process required for endometriosis. In a rat endome…

OBJECTIVE: To determine the pregnancy rate after bowel resection for rectosigmoid endometriosis. DESIGN: Prospective cohort study. SETTING: University hospital. PATIENT(S): Forty-six symptomatic women with bowel endometriosis requiring c…

OBJECTIVE: To identify issues related to fertility preservation, discuss the state of the science, and make specific recommendations to guide future research supported by the U.S. National Institutes of Health in the field of fertility pres…