Effects of testosterone and metformin on glucose metabolism in endometrium

Lei Zhang, Zhang L, Liao Q, Qinping Liao
Fertility and sterility · 2009 · vol. 93(7) , pp. 2295–2298 · doi:10.1016/j.fertnstert.2009.01.096 · PMID:19328476 · W1966524315
article OA: closed CC0 ⤵ 4 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study investigated the impact of testosterone and metformin on glucose metabolism within endometrial tissue.

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Abstract

ObjectiveTo investigate the effects of testosterone and metformin on glucose metabolism in endometrium.DesignIn vitro experiment.SettingReproductive and Genetic Center, Obstetrics and Gynecology, The First Hospital of Peking University, Beijing, China.Patient(s)Premenopausal women undergoing total abdominal hysterectomy for uterine myoma or adenomyosis.Intervention(s)Endometrial glandular epithelial cell culture.Main outcome measure(s)Insulin receptor substrate-1 (IRS-1) and glucose transporter 4 (GLUT-4) expression in endometrial glandular epithelial cell.Result(s)After the action of testosterone solution, the protein expressions of IRS-1mRNA, IRS-1, and GLUT-4 in endometrial glandular epithelial cells all decreased significantly. Metformin may reverse this effect.Conclusion(s)The high androgen levels in patients with polycystic ovary syndrome could induce insulin resistance in endometrial glandular epithelial cell, whereas metformin has an antagonizing effect.

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Condition tags

endometriosis

MeSH descriptors

Endometrium Endometrium Glucose Metformin Testosterone Adult Cells, Cultured Endometriosis Endometriosis Endometriosis Endometrium Endometrium Epithelial Cells Epithelial Cells Epithelial Cells Female Follicular Phase Follicular Phase Gene Expression Regulation Gene Expression Regulation

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