Glucose transporters in the uterus: an analysis of tissue distribution and proposed physiological roles

Antonina I. Frolova, Kelle H. Moley
In: Reproduction · 2011 · vol. 142(2) , pp. 211–220 · doi:10.1530/rep-11-0114 · PMID:21642384 · W2073312761
review OA: bronze CC0 ⤵ 3 in-corpus citations
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This review analyzes glucose transporter expression and distribution in the uterus, exploring their roles in normal physiology and pathological conditions like infertility and endometrial cancer.

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Abstract

Facilitative glucose transport molecules (glucose transporters, GLUTs) are responsible for glucose transport across cellular membranes. Of the 14 family members, expression of nine has been reported in the murine uterus and seven in the human uterus. Some studies reveal that adequate glucose uptake and metabolism are essential for the proper differentiation of the uterine endometrium toward a receptive state capable of supporting embryo implantation. However, the mechanistic role of GLUTs in endometrial function remains poorly understood. This review aims to present the current knowledge about GLUT expression in the uterus and distribution among the different cell types within the endometrium. In addition, it analyzes the available data in the context of roles GLUTs may play in normal uterine physiology as well as the pathological conditions of infertility, endometrial cancer, and polycystic ovarian syndrome.

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infertility

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