Estradiol modulation of hepatocyte growth factor by stromal fibroblasts in the female reproductive tract

Kimberly D. Coleman, Coleman KD, Wright JA, Jacqueline A. Wright, Ghosh M, Mimi Ghosh, Charles R. Wira, Wira CR, Fahey JV, John V. Fahey
Fertility and sterility · 2009 · vol. 92(3) , pp. 1107–1109 · doi:10.1016/j.fertnstert.2008.10.047 · PMID:19423096 · PMC4322385 · W2009830841
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

Estradiol influences stromal fibroblasts in the female reproductive tract to modulate hepatocyte growth factor, affecting tissue growth and repair.

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Abstract

Primary human uterine, cervical, and ectocervical stromal fibroblasts constitutively secrete hepatocyte growth factor (HGF), yet only uterine stromal fibroblasts increase HGF secretion in response to estradiol. Estradiol-induced HGF secretion by uterine stromal fibroblasts may have a significant effect on uterine cancer and endometriosis.

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MeSH descriptors

Cervix Uteri Estradiol Fibroblasts Hepatocyte Growth Factor Stromal Cells Uterus Adult Aged Cell Communication Cell Communication Cell Proliferation Cell Proliferation Cells, Cultured Cervix Uteri Cervix Uteri Dose-Response Relationship, Drug Epithelial Cells Epithelial Cells Epithelial Cells Estradiol

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