American journal of obstetrics and gynecology

Cytosol estrogen (ER) and progestin (PR) receptors were quantified in 47 endometriosis lesions from 41 patients and compared with receptor measurements in the endometrial tissue of nine of these patients. Half of the specimens of endometrio…

As an alternative to hysterectomy in patients with excessive bleeding, the endometrium was destroyed by means of the neodymium-YAG laser. The photovaporization was done under direct vision through a hysteroscope. Twenty-two patients have be…

Prostaglandins E and F (PGE, PGF) and their 13,14-dihydro-15-keto metabolites were measured by radioimmunoassay in myometrium obtained from 27 women during abdominal hysterectomy for benign gynecologic conditions at defined stages of the me…

In a double-blind, crossover study of 32 women with primary dysmenorrhea, the analgesic efficacy of naproxen sodium was compared to that of aspirin and placebo. The treatment started 1 to 5 days before the onset of menses and continued for …

An anatomic basis for the infertility associated with endometriosis is often lacking. The present study measured peritoneal fluid levels of two of the stable products of prostaglandin endoperoxides (thromboxane B2 and 6-keto-prostaglandin F…

Information on reproductive history, gynecologic operations, and examinations was analyzed for 338 diethylstilbestrol (DES)-exposed and 298 unexposed women whose mothers participated in an evaluation of DES use in pregnancy 28 years ago. A …

There have been 17 reported cases of histologically proved thoracic endometriosis and 27 cases of probable thoracic endometriosis based upon repetitive symptoms associated with menstruation and response to suppression of ovarian function. T…

Danazol, an isoxazol derivative of ethinyl testosterone which suppresses gonadotropin levels and acts as a weak androgen, is shown by competition studies to bind rat androgen receptor (Ki 10(-8M) and progestin receptor (Ki 10(-7)M) but not …

Three groups of women with benign breast disease were treated with danazol for 3 to 6 months. Doses of 100 mg per day were given to 40 patients, 200 mg to 55, and 400 mg to 35. The age range of the patients was 20 to 48 years. The patients …

Endometrial adenocarcinoma and adenomyosis are both common problems arising in the uterus. Interestingly, there are few reports of the combination of these two pathologic entities. A recent experience with eight cases found in the files of …

The action of danazol on 125I-human chorionic gonadotropin (hCG) binding, gonadotropin-stimulated adenosine 3',5' cyclic monophosphate (cAMP) accumulation and progesterone production has been investigated in luteinized rat ovaries. Preincub…

This descriptive study presents 230 women with the chief or major complaint of pain during intercourse. The patients were assessed according to the medical model with careful screening for intrapersonal (intrapsychic), interpersonal (relati…

Systematic genetic studies in endometriosis apparently have not been conducted; therefore, we studied 123 patients with histologically proved endometriosis. Nine of 153 (5.8%) female sibs (over age 18) of patients with histologically proved…

Clinical characteristics of patients with histologically confirmed pelvic endometriosis who had an affected first-degree relative (N = 18) were compared to those who had no such affected relative (N = 105). The only significant difference w…

The effects of danazol on the luteal phase of cycling rhesus monkeys and on the ability of the intact rhesus monkey to respond to hCG stimulation were studied in two experiments. In a third experiment the impact of danazol upon the response…

Myometrial tissues from 36 women who underwent hysterectomy at various stages of the menstrual cycle were examined in the electron microscope for the presence of gap junctions. Gap junctions were present between smooth muscle cells in some …