American journal of obstetrics and gynecology

The clinical applicability of danazol has been postulated to depend upon its antigonadotropic and androgenic properties. However, the true mechanism of action of danazol has not been fully elucidated, and experimental evidence indicates tha…

The developing genital tract of the fetal mouse was exposed to diethylstilbestrol (DES) and the induction of noncyclic ovarian function in adult life was circumvented. Female mice of two inbred strains, BALB/c and C3H, were mated with BALB/…

Recent literature has suggested that the majority of pregnancies following a laparoscopic tubal coagulation failure are ectopic. This is in direct contrast to the failure of other types of tubal ligation procedures which usually result in i…

The review of a 3-year, 500-case experience has revealed a marked change in the indications for infertility laparoscopy that has evolved over the past decade. In cases of unexplained infertility, 44% of 182 laparoscopies disclosed unsuspect…

In an attempt to clarify further the relationship between ovarian function and uterine leiomyomas, we investigated the cytoplasmic estrogen and progesterone receptor content in these uterine tumors. The study population consisted of 17 wome…

The volume of peritoneal fluid and its macrophage content were examined in 80 women undergoing laparoscopy. The amount of pelvic fluid was not dependent on the patency of the fallopian tubes, and no statistical difference in the fluid volum…

Late proliferative (days 9 to 14) and midsecretory (days 18 to 24) human endometria were maintained in organ culture in the presence of 17 beta-estradiol and/or progesterone or mefenamic acid 17 beta-estradiol (0.1 to 1,000 ng/ml) increased…

The mechanism of infertility in women with endometriosis is unknown, but it is independent of mechanical factors that affect fallopian tube function. Increased numbers of peritoneal macrophages are present in women with endometriosis and ha…

Analysis of published series indicates that, irrespective of the method of data collection, close agreement exists on empirically derived incidences of spontaneous abortion in North American populations, provided that age, previous abortion…

Twenty patients with endometriosis diagnosed by laparoscopy were treated with the antiestrogen, antiprogesterone gestrinone (R-2323) for 6 to 8 months. The drug was administered in a dose of 5 mg twice weekly. According to the American Fert…

The mechanism of action of danazol has not been established and the drug may act at multiple loci. Effects suggesting inhibition of pituitary gonadotropin release have been described while some in vitro studies have demonstrated competitive…

The nuclear uptake and retention of 3H-dehydrotestosterone (3H-DHT) were studied in the reproductive organs of the female rhesus monkey by autoradiography. Ovariectomized and adrenalectomized adult female monkeys were injected with 1 microg…

We studied the effects of danazol on pituitary and gonadal function in seven normal women who volunteered to take danazol, 400 mg twice daily, for 2 months. We measured circulating levels of sex steroids, gonadotropins, and prolactin on alt…

The options for the medical management of endometriosis have been expanded by the introduction of the synthetic steroid, danazol. The results of large clinical studies suggest that danazol treatment produces significant improvement in the s…

The use of danazol (Danocrine) appears to be the most effective medical form of therapy for endometriosis. A double-blind study on 32 patients with laparoscopically proved pelvic endometriosis was designed to evaluate the immediate short-te…

Life-table estimation of cumulative pregnancy curves following infertility therapy is an important tool for evaluating the effectiveness of therapy. However, a satisfactory method for summarizing an entire cumulative pregnancy curve in term…