Karin Hellner

Endometriosis is a chronic inflammatory condition characterised by the presence of endometrium-like tissue outside the uterus. Despite its high prevalence and recent advances in molecular science, many aspects of endometriosis and its patho…

The complex and dynamic cellular composition of the human endometrium remains poorly understood. Previous endometrial single-cell atlases profiled few donors and lacked consensus in defining cell types. We introduce the Human Endometrial Ce…

Immunological dysregulation plays a fundamental role in the inflammatory aspects of endometriosis. Circulating blood leukocytes, one of the most abundant immune cell populations in the human body, have been shown diagnostic significance in …

Abstract The human endometrium, the inner lining of the uterus, exhibits complex, dynamic changes throughout the menstrual cycle in response to ovarian hormones. Aberrant response of endometrial cells to hormones is associated with multiple…

Endometriosis affects up to 10% of premenopausal women causing pelvic pain and infertility. Whilst the pathogenesis remains unclear, estrogen-dependence and inflammation play a key role. Currently, laparoscopic surgery is the diagnostic gol…

Endometriosis affects 5-10% of premenopausal women causing pelvic pain and impaired fertility. Diagnosis can only be established surgically, thus, less invasive means of diagnosis are urgently needed. Endometriosis has been suggested to ind…

Genome-wide association studies in the fields of reproductive medicine and endocrinology are yielding robust genetic variants associated with disease. Integrated genomic, transcriptomic, and epigenomic molecular profiling studies are common…