Peripheral Basophil Count is Increased in Patients with Endometriosis.

Qingchun Feng, Nilüfer Rahmioğlu, Kevin Paddon, Catherine S. Hubbard, Krina T. Zondervan, Christian M. Becker, Karin Hellner
2018 · vol. 25 · W2902060760
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-07-09 ⓘ

This study investigated peripheral leukocyte subtypes as potential biomarkers for endometriosis and found an increased basophil count in affected patients.

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⚙ AI-generated deep summary by claude@2026-07, 2026-07-09 · read from full text ⓘ

The paper studied whether leukocyte subtype counts from routine full blood count tests could serve as biomarkers for endometriosis, motivated by the estrogen-dependence and inflammatory mechanisms underlying the disease. Using peripheral blood measurements, the key finding was that peripheral basophil counts were increased in patients with endometriosis compared with controls, supporting basophils as a potential circulating biomarker. A major caveat is that the work is an accepted manuscript/conference item, and laparoscopic surgery is still described as the diagnostic gold standard, implying clinical validation and diagnostic performance were not fully established within this report. This paper is centrally about endometriosis — it specifically reports that peripheral basophil counts are increased in patients with endometriosis.

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Abstract

Endometriosis affects up to 10% of premenopausal women causing pelvic pain and infertility. Whilst the pathogenesis remains unclear, estrogen-dependence and inflammation play a key role. Currently, laparoscopic surgery is the diagnostic gold standard. Thus, an urgent unmet clinic need for a minimally invasive and widely available diagnostic tool exists. Levels of circulating leukocytes have been suggested as potent biomarkers for various conditions and can be extracted from routine full blood count (FBC) tests. This study investigates the potential value of leukocyte subtypes as biomarkers for endometriosis.
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Conference item Peripheral basophil count is increased in patients with endometriosis - Abstract: - Endometriosis affects up to 10% of premenopausal women causing pelvic pain and infertility. Whilst the pathogenesis remains unclear, estrogen-dependence and inflammation play a key role. Currently, laparoscopic surgery is the diagnostic gold standard. Thus, an urgent unmet clinic need for a minimally invasive and widely available diagnostic tool exists. Levels of circulating leukocytes have been suggested as potent biomarkers for various conditions and can be extracted from routine full blood count (FBC) tests. This study investigates the potential value of leukocyte subtypes as biomarkers for endometriosis. - Publication status: - Published - Peer review status: - Peer reviewed Actions Access Document - Files: - - (Preview, Accepted manuscript, pdf, 257.3KB, Terms of use) - - Publisher copy: - 10.1177/1933719118759999 Authors - Publisher: - SAGE Publications - Host title: - 65th Annual Meeting of the Society for Reproductive Investigation (SRI 2018) - Journal: - 65th Annual Meeting of the Society for Reproductive Investigation (SRI 2018) More from this journal - Publication date: - 2018-02-28 - Acceptance date: - 2017-12-26 - DOI: - EISSN: - 1933-7205 - ISSN: - 1933-7191 - Keywords: - Pubs id: - pubs:846789 - UUID: - uuid:3f2a7544-b910-43c2-98fb-5c7054d12b93 - Local pid: - pubs:846789 - Source identifiers: - 846789 - Deposit date: - 2018-06-16 - ARK identifier: Terms of use - Copyright holder: - Society for Reproductive Investigation - Copyright date: - 2018 - Notes: - Copyright © 2018 by Society for Reproductive Investigation. This is the accepted manuscript version of the article. The final version is available online from SAGE Publications at: https://doi.org/10.1177/1933719118759999 If you are the owner of this record, you can report an update to it here: Report update to this record

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