Sachiko Matsuzaki

BACKGROUND: The aim of this study was to investigate HOXA-10 expression in endometrium from infertile patients with different forms of endometriosis; with uterine fibromas, or with unexplained infertility and from normal fertile women. METH…

Expression levels of 8-hydroxydeoxyguanosine, a sensitive indicator of DNA damage resulting from oxidative stress, were significantly higher in samples of normal ovarian cortex surrounding endometriotic cysts when compared with ovarian cort…

Endometriosis, a common gynecological disorder responsible for infertility and pelvic pain, is defined as the presence of endometrial glands and stroma within extra-uterine sites. Gene expression studies performed on endometriotic tissue ho…

OBJECTIVE: To evaluate the effect of protein kinase C inhibition on surgically induced endometriosis in mice. DESIGN: Prospective, randomized study. SETTING: Academic facility. ANIMALS: Sixty adult female C57BJ6 mice. INTERVENTION(S): O…

The minimum distance between the vaginal mucosal epithelium and the endometriotic glands was <1,000 microm in 30 patients (49.2%), <2,000 microm in 44 patients (72.1%), and <5,000 microm in 60 patients (98.4%). Our findings provided histolo…

ObjectiveWith a prospective study, to evaluate the existence of two distinct clinical diseases in the endometriosis syndrome, by comparing pain symptoms and quality of life from patients with minimal endometriosis (AFS-R<5) and data from pa…

L’endométriose est une maladie bénigne, très invalidante et fréquente, définie par la présence d’endomètre, épithélium et stroma, en situation ectopique. Sa physiopathologie, et celle des douleurs qui l’accompagnent, est mal connue. Les sig…

Resume ´ : L'endometriose est une maladie benigne, tres invalidante et frequente, definie par la presence d'endo- metre, epithelium et stroma, en situation ectopique. Sa physiopathologie, et celle des douleurs qui l'accompa- gnent, est mal …

OBJECTIVE: To investigate mRNA expression of aromatase and 17beta-hydroxysteroid dehydrogenase type 2 (17betaHSD2) in epithelial and stromal cells from eutopic and ectopic endometrium of patients with deep endometriosis. DESIGN: Prospectiv…

ObjectiveTo investigate whether genes that had been found to be differentially expressed in deep-infiltrating endometriosis and matched eutopic endometrium in our previous complementary DNA microarray study also are differentially expressed…

ObjectiveTo investigate whether WT1 protein expression is altered in eutopic endometrium of endometriosis patients.DesignProspective study.SettingUniversity hospital.Patient(s)Patients with endometriosis and fertile women with macroscopical…

We investigated relationships between delay of surgical diagnosis and severity of disease in 95 patients with symptomatic deep infiltrating endometriosis. The delay before surgical diagnosis of deep infiltrating endometriosis was significan…

ObjectiveTo investigate differentially expressed genes in epithelial and stromal cells of eutopic endometrium from patients with deep endometriosis and women with normal pelvic cavities using laser capture microdissection and complementary …

some obvious plausibility, as witness the fact that many critically intelligent people believe it (as I did until it mattered to me and I looked for the evidence).It is apparently so very plausible that no one has bothered to prove it (or t…

ObjectiveTo identify any relationship between cyclooxygenase-2 expression and the intensity of severe, endometriosis-related dysmenorrhea.DesignProspective study.SettingUniversity hospital.Patient(s)Patients with deep endometriosis.Interven…

OBJECTIVE: To evaluate Cox-2 inhibition on surgically induced endometriosis in rats. DESIGN: Prospective, randomized study SETTING: Academic facility. ANIMAL(S): Seventy adult female Sprague-Dawley rats. INTERVENTION(S): Uterine fragmen…