Is the dose to inhibit the COX-2 enzyme in nude mice also adequate in ‘human’ endometrial tissues?
letter
OA: bronze
CC0
⤵ 3 in-corpus citations
AI-generated summary
This paper questions whether the COX-2 inhibiting dose used in nude mice is effective in human endometrial tissues, noting a lack of supporting evidence despite widespread belief.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
some obvious plausibility, as witness the fact that many critically intelligent people believe it (as I did until it mattered to me and I looked for the evidence).It is apparently so very plausible that no one has bothered to prove it (or to pay attention to such evidence to the contrary as is available in the very references included with these letters).This is much like the legendary double-ovulation origin of natural human dizygotic twinning (Boklage, 2005). ReferencesBoklage CE (1990) Survival probability of human conceptions from fertilization to term.Int J Fertil 35,75-94.Boklage CE (2005) The biology of human twinning: a needed change of perspective.In
My notes (saved in your browser only)
Condition tags
MeSH descriptors
Citation neighborhood (sparse)
Too few in-corpus citations on either side for a chart; here are the lists.
Cites (3)
- Distribution of cyclooxygenase-2 in eutopic and ectopic endometrium in endometriosis and adenomyosis 2001
- Cyclooxygenase-2 expression in deep endometriosis and matched eutopic endometrium 2004
- Nimesulide, a COX-2 inhibitor, does not reduce lesion size or number in a nude mouse model of endometriosis 2004
Cited by (3)
- Selective Inhibition of Prostaglandin E2 Receptors EP2 and EP4 Induces Apoptosis of Human Endometriotic Cells through Suppression of ERK1/2, AKT, NFκB, and β-Catenin Pathways and Activation of Intrinsic Apoptotic Mechanisms 2009
- Suppression of IL-1β-induced COX-2 expression by trichostatin A (TSA) in human endometrial stromal cells 2007
- Selective Inhibition of Prostaglandin E2 Receptors EP2 and EP4 Induces Apoptosis of Human Endometriotic Cells through Suppression of ERK1/2, AKT, NFκB and β-CATENIN Pathways and Activation of Intrinsic Apoptotic Mechanisms 2009
References (4)
- Cyclooxygenase-2 expression in deep endometriosis and matched eutopic endometrium via openalex
- Distribution of cyclooxygenase-2 in eutopic and ectopic endometrium in endometriosis and adenomyosis via openalex
- Nimesulide, a COX-2 inhibitor, does not reduce lesion size or number in a nude mouse model of endometriosis via openalex
- W2040095832 via openalex
Cited by (3)
- Selective Inhibition of Prostaglandin E2 Receptors EP2 and EP4 Induces Apoptosis of Human Endometriotic Cells through Suppression of ERK1/2, AKT, NFκB, and β-Catenin Pathways and Activation of Intrinsic Apoptotic Mechanisms 2009
- Selective Inhibition of Prostaglandin E2 Receptors EP2 and EP4 Induces Apoptosis of Human Endometriotic Cells through Suppression of ERK1/2, AKT, NFκB and β-CATENIN Pathways and Activation of Intrinsic Apoptotic Mechanisms 2009
- Suppression of IL-1β-induced COX-2 expression by trichostatin A (TSA) in human endometrial stromal cells 2007
Source provenance
- europepmc
- last seen: 2026-08-23T09:30:01.253652+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:15:35.797702+00:00
License: CC0
· commercial use OK