Zhang X

BackgroundImpaired decidualization is associated with recurrent implantation failure (RIF) and lysophosphatidic acid (LPA) is known to play an important role in decidua formation. However, the specific impact of LPA in endometrial deciduali…

Although tumor-associated macrophages (TAMs) play a critical immunomodulatory role in colorectal cancer (CRC), the mechanisms underlying their polarization remain unclear. This study identifies the P2X4 receptor (P2X4R) as a crucial mediato…

Skin cutaneous melanoma (SKCM) is a highly aggressive malignancy, and understanding the mechanisms underlying its metastasis is essential for improving patient prognosis. N6-methyladenosine (m6A) RNA modification is involved in tumor progre…

Ming Wei,1 Weijun Liu,1– 3 Zhangqiang Zheng,1 Yun Liu,1 Xingzhou Zhang1 1Tianjin NanKai Hospital, Tianjin Medical University, Tianjin, People’s Republic of China; 2Department of Scientific Research, Tianjin Key Laboratory of Acute Abdomen D…

INTRODUCTION: Endometriosis is a prevalent chronic gynecological disease, characterized by the growth of endometrial glands and stroma outside the uterus and by the presence of chronic inflammatory lesions. This condition is one of the most…

BackgroundOvarian cancer has poor treatment outcomes. This study aims to explore the clinical importance of LINC00886 and its effects on cancer cell behavior in ovarian cancer, potentially offering a new therapeutic target.Materials and met…

Abstract Background/Objectives: To study the molecular classification of endometrial cancer combined with adenomyosis and compare its differences in molecular classification and clinicopathological characteristics with endometriosis ade…

The studies on how mast cells mediate endometriosis pain are still limited. Mas-related G protein-coupled receptor member X2 (MRGPRX2), a receptor expressed on mast cells, participates in pain, inflammation, and itch. However, it is still u…

BackgroundOvarian dysfunction caused by aging restricts female reproductive capacity and causes age-related health problems. Ferroptosis is an important mode of cell death during accelerated aging. Oviductus Ranae (OR), a traditional Chines…

OBJECTIVE: To evaluate whether perinatal and infant outcomes differ between singleton births after assisted reproductive technology (ART) in women with endometriosis alone and those with other causes of infertility. DESIGN: Population-base…

Endometriosis (EM), a gynecologic disorder affecting 10 % of childbearing age women, with complex pathogenesis involving cell proliferation and metabolic abnormalities similar to malignancies. Unusual expression of key enzymes and regulator…

Previous research has indicated that Polyphyllin I (PPI) possesses potent anticancer properties. However, its impact on endometriosis remains unexplored. This study aims to investigate the inhibitory effects of PPI on ectopic endometrial st…

ObjectivesTo estimate the prevalence of urinary incontinence (UI) and its subtypes among nulliparous Chinese women with associated risk factors. The prevalence of UI among those living in urban or rural communities was also analysed with po…

Endometriosis (EM) is a chronic inflammatory disease that is one of the most common causes of gynecological systemic lesions in women before menopause. The most representative histological feature of EM is that the endometrium appears outsi…

Non-invasive prenatal testing (NIPT) not only enables the detection of chromosomal anomalies in fetuses but also generates vast amounts of ultra-low-depth sequencing data, which can be leveraged for population genomic studies. Here, we pres…

Organoids are three-dimensional tissue analogues grown in vitro. Although they are not human organs in the strict sense, they can mimic the structure and function of tissues in vivo to the maximum extent, and have broad application prospect…

Congenital cervical and vaginal atresia in the presence of a functioning endometrium is an extremely rare disease. Cervicovaginal reconstruction preserves fertility for these patients. We present the case of a 20-year-old patient who had ce…

The hyaluronic acid synthase (HAS) family participates in key physiological processes such as follicular development, oocyte maturation, ovulation, and embryo implantation by regulating the synthesis of hyaluronic acid, and plays an importa…

OBJECTIVE: This study explored the incidence of adverse events (AEs) following microwave ablation (MWA) under local anesthesia and analyzed factors related to benign uterine diseases, including uterine fibroids (UFs) and adenomyosis (AM). …

BackgroundBronchopulmonary dysplasia (BPD) is a common chronic respiratory disease in preterm infants, and its incidence has gradually increased with advances in medical technology. BPD is associated with multiple complications, significant…

Background and objectivesMultimorbidity is increasingly prevalent among the middle-aged population, yet it is largely often overlooked. We aimed to explore and compare the differences in multimorbidity patterns by sex and age among middle-a…

BackgroundMultimorbidity substantially increases health and economic burdens, and reduces productivity in working-age individuals. We conducted a study using data from 393,170 working-age inpatients (18-59 years) in Shaanxi, China, collecte…

BackgroundPolycystic ovary syndrome (PCOS) and type 2 diabetes mellitus (T2DM) are two prevalent and interrelated disorders that pose an increasingly significant global health burden. Cellular senescence may represent a pivotal process driv…

At the maternal-fetal interface, tightly regulated levels of retinoic acid (RA), the physiologically active metabolite of vitamin A, are required for embryo implantation and pregnancy success. Herein, we utilize mouse models, primary human …

BACKGROUND: Numerous previous studies have suggested dyslipidemia is possibly linked to endometriosis (EMs). The connection between endometriosis and NHHR remains largely unexplored. Thus, this investigation examined whether NHHR is correla…