Naoki Terakawa

No ORCID on file · 77 papers in corpus · active 1986-2021

Study types

  • article 62
  • review 6
  • other 3
  • book-chapter 2
  • case-report 1

Condition tags

  • mesh:D004715 46
  • endometriosis 39
  • endometrioma 9
  • infertility 6
  • mesh:D017699 4
  • mesh:D004412 3
  • dysmenorrhea 3
  • dyspareunia 2
  • mesh:D004414 2
  • chronic_pelvic_pain 1
rct 2021
Relugolix, an oral gonadotropin-releasing hormone (GnRH) receptor antagonist, in women with endometriosis-associated pain: phase 2 safety and efficacy 24-week results
BMC women's health ·doi:10.1186/s12905-021-01393-3

BACKGROUND: Relugolix is a once-daily, oral, nonpeptide, gonadotropin-releasing hormone receptor antagonist. The aim of this study was to evaluate safety of relugolix over 24 weeks in women with endometriosis-associated pain. METHODS: This…

article 2020
Relugolix, an oral gonadotropin-releasing hormone receptor antagonist, reduces endometriosis-associated pain in a dose–response manner: a randomized, double-blind, placebo-controlled study
Fertility and sterility ·doi:10.1016/j.fertnstert.2020.07.055
article 2017
Relugolix, an oral gonadotropin-releasing hormone (GnRH) receptor antagonist, in women with endometriosis (EM)-associated pain: Phase 2 safety and efficacy 24-week results
·doi:10.1530/endoabs.49.gp134

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

article 2016
Lipopolysaccharide promotes the development of murine endometriosis-like lesions via nuclear factor-kappa B pathway
·doi:10.1016/j.fertnstert.2016.07.781
article 2015
Pelvic inflammation via toll-like receptor4 promotes the development of endometriosis-like lesions in the murine model
·doi:10.1016/j.fertnstert.2015.07.509
article 2014
Clinical Characteristics of Patients in Japan with Ovarian Cancer Presumably Arising from Ovarian Endometrioma
Gynecologic and obstetric investigation ·doi:10.1159/000357819

OBJECTIVE: To investigate the clinical features of patients in Japan with malignant transformation of ovarian endometrioma. PATIENTS: Thirty-three patients diagnosed with ovarian cancer presumably arising from endometrioma were recruited re…

article 2014
Iap inhibitor represses inflammation and the development of endometriosis-like lesions in a murine model
·doi:10.1016/j.fertnstert.2014.07.171
article 2014
The bacterial endotoxin enhances development of endometriosis-like lesions in murine model
·doi:10.1016/j.fertnstert.2014.07.039
review 2013
Epigenetic aberration of gene expression in endometriosis
Frontiers in bioscience (Elite edition) ·doi:10.2741/e669

Endometriosis is an estrogen-dependent inflammatory disease. In endometriotic tissues, a high-estrogen environment associated with up-regulation of the aromatase gene has been well documented. There is accumulating evidence supporting a con…

article 2013
Fibroblast Growth Factor Receptor 2 Expression May Be Involved In Transformation of Ovarian Endometrioma to Clear Cell Carcinoma of the Ovary
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society ·doi:10.1097/igc.0b013e31828f38c4
article 2012
Gonadotropin-Releasing Hormone Analogues Reduce the Proliferation of Endometrial Stromal Cells but Not Endometriotic Cells
Gynecologic and obstetric investigation ·doi:10.1159/000343748

AIMS: We investigated the potential of gonadotropin-releasing hormone (GnRH) agonists and GnRH antagonists to inhibit cell proliferation in endometriotic and endometrial stromal cells. METHODS: Twenty patients with ovarian endometriomas and…

article 2012
Inhibitor of apoptosis protein (IAP)-2 is a novel therapeutic target for endometriosis
·doi:10.1016/j.fertnstert.2012.07.340
article 2012
The NFκB inhibitor parthenolide reduces cell proliferation and PGE2 synthesis in human endometriotic stromal cells and inhibits development of endometriosis in murine model
·doi:10.1016/j.fertnstert.2012.07.339
review 2012
The role of NF-kappaB in endometriosis
Frontiers in bioscience (Scholar edition) ·doi:10.2741/s327

The nuclear factor kappaB (NF-kappaB) is a ubiquitously expressed transcription factor playing vital roles in innate immunity and other processes involving cellular survival, proliferation, and differentiation. This review highlights the im…

book-chapter 2011
Aberrant Expression of IAP Family in Endometriotic Cells May Cause Resistance to Apoptosis
·doi:10.1210/endo-meetings.2011.part3.p25.p3-172
book-chapter 2011
A Hypomethylated CpG Island in the Aromatase Gene May Cause Up-Regulation in Endometriotic Cells
·doi:10.1210/endo-meetings.2011.part3.p25.p3-181
article 2011
TNFα is a potent mediator of regulating IAP expression in endometriotic cells
·doi:10.1016/j.fertnstert.2011.07.534
article 2010
Aberrant expression of IAP family in endometriotic cells may cause resistance to apoptosis
·doi:10.1016/j.fertnstert.2010.07.779
article 2010
Apigenin inhibits tumor necrosis factor α–induced cell proliferation and prostaglandin E2 synthesis by inactivating NFκB in endometriotic stromal cells
·doi:10.1016/j.fertnstert.2010.09.046
review 2010
Apoptosis and endometriosis
Frontiers in bioscience (Elite edition) ·doi:10.2741/e277

Apoptosis is a distinctive form of programmed cell death resulting in the efficient elimination of cells without eliciting an inflammatory response. Endometriosis is characterized by the presence of endometrial cells with capacity to avoid …

article 2010
Demethylation of a nonpromoter cytosine-phosphate-guanine island in the aromatase gene may cause the aberrant up-regulation in endometriotic tissues
Fertility and sterility ·doi:10.1016/j.fertnstert.2010.06.024
article 2009
Lipopolysaccharide promoted proliferation and invasion of endometriotic stromal cells via induction of cyclooxygenase-2 expression
Fertility and sterility ·doi:10.1016/j.fertnstert.2009.06.042
other 2009
Long-term use of dienogest for the treatment of endometriosis
Journal of Obstetrics and Gynaecology Research ·doi:10.1111/j.1447-0756.2009.01076.x

AIM: To investigate the safety and efficacy of 52 weeks of dienogest treatment in patients with endometriosis. METHODS: One hundred and thirty-five patients with endometriosis received 2 mg of dienogest orally each day for 52 weeks. Advers…

article 2009
ORIGINAL ARTICLE: TNFα Gene Silencing Reduced Lipopolysaccharide‐Promoted Proliferation of Endometriotic Stromal Cells
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/j.1600-0897.2009.00691.x

PROBLEM: We previously reported that lipopolysaccharide (LPS)-promoted endometriotic stromal cell (ESC) proliferation by inducing TNFalpha production. The aim of this study was to investigate the efficacy of TNFalpha gene silencing on LPS-t…

article 2009
Possible involvement of survivin in resistance to drug-induced apoptosis of endometriotic stromal cells
·doi:10.1016/j.fertnstert.2009.07.1102