Xu S

ObjectiveTo compare the postoperative analgesic efficacy of oliceridine versus sufentanil in patients undergoing total laparoscopy hysterectomy.MethodsIn this double-blind, randomized controlled trial, 80 patients scheduled for elective tot…

Exposure to harmful environments during pregnancy and maternal nutritional status are key factors that affect offspring development; however, the underlying mechanisms of maternal-fetal interaction remain to be elucidated. In recent years, …

Oocyte/embryo defects can result in oocyte maturation arrest, fertilization failure, embryonic arrest, and infertility as well as recurrent in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) failures. However, the genet…

Growing evidence highlights the role of microbiota, including those of the gut, reproductive tract, and endometrial tissue, as critical functional drivers in the pathogenesis of endometriosis (EM). Studies have revealed a characteristic mic…

PURPOSE: Adenomyosis (AM) with dysmenorrhea (AMD) is a global public health concern that may involve abnormal brain function and heightened vulnerability to anxiety and depression. This study aimed to investigate static and dynamic regional…

Ovarian endometriosis (OvE) is a gynecological disorder with endometrial tissue in the ovaries, for which effective non-invasive diagnosis and curative treatments are currently lacking. Serum samples were collected from both discovery and v…

This study investigates the role of carbohydrate antigen 125 (CA125) in the pathogenesis of systemic lupus erythematosus (SLE) and analyzes factors associated with its elevation. A total of 220 patients diagnosed with SLE at the Department …

Gut microbial β-glucuronidase (GUS) plays a pivotal role at the microbiota-host interface by hydrolyzing glucuronide conjugates, thereby influencing xenobiotic metabolism, enterohepatic circulation, and systemic homeostasis. Dysregulated GU…

PurposeThe International Federation of Gynecology and Obstetric (FIGO) stage is critical to guiding the treatments of ovarian cancer (OC). We tried to develop a model to predict the FIGO stage of OC through machine learning algorithms with …

The diverse and dynamic population of microorganisms present in the gut microbiota may affect host health. There are evidences to support the role of gut microbiota as a key player in reproductive development. Unfortunately, the relationshi…

Abstract Background: Endometrial receptivity, a critical prerequisite for successful pregnancy, is impaired in women with endometriosis. Plasma membrane transformation (PMT), a key process involving dynamic remodeling of endometrial epithe…

BACKGROUND: Endometriosis is a major contributor to infertility and pelvic pain, which brings a significant burden on family and society. Although the data of endometriosis in Global Burden of Disease (GBD) 2019 was reviewed, no updated ana…

Background: Both intramural myomas and thin endometrium exert a detrimental influence on the outcomes of assisted reproductive technology (ART). The downregulation of gonadotropin releasing hormone agonists (GnRH-a) is regarded as an effect…

Longlong Wei,1,2 Bing Tian,2 Shuna Wang,2 Siyue Xu,2 Cuilian Zhang1,2 1People’s Hospital of Zhengzhou University, Zhengzhou, Henan, 45003, People’s Republic of China; 2Department of Reproductive Medicine Center, Henan Provincial People’s Ho…

Histone lactylation is crucial in a variety of physiopathological processes; however, the function and mechanism of histone lactylation in endometriosis remain poorly understood. Therefore, the objective of this investigation was to illumin…

As the fertility risks for older males such as infertility and reduced success rates are on the rise, an increasing number of individuals are turning to Assisted Reproductive Technology (ART) to have offspring. However, the influence of pat…

Abstract Delayed diagnosis of endometriosis (EM) can significantly hinder treatment options and patient prognosis, adversely affecting fertility and increasing the risk of malignancy. Current diagnostic methods are invasive. In our study, …

MicroRNAs (miRNAs) are a class of non-coding RNA. MiRNAs affect physiological processes by regulating messenger RNA (mRNA) translation of target genes. The peri-implantation period is the period with the most loss of pig embryos, during whi…

OBJECTIVE: To evaluate the effects of a P2X4 receptor (P2X4R)-specific antagonist on murine endometriotic-like lesions and human endometriotic stromal cells. DESIGN: Experimental study using an in vivo mouse endometriosis model and in vitr…

OBJECTIVES: This study aimed to investigate the distribution of molecular signatures in endometriosis- associated ovarian cancer (EAOC) and to develop a prognostic model based on these molecular signatures. METHODS: We retrospectively analy…

Adenomyosis is a complex gynecological disease characterized by endometrial tissue invasion into the myometrium. Current interventions, such as hormonal therapy or hysterectomy, are associated with significant side effects and compromise fe…

ObjectiveTo explore the correlation between antinuclear antibodies (ANAs) and pregnancy loss (PL), and to observe its impact on the pregnancy outcomes of in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) …

BACKGROUND: Tubal ectopic pregnancy (TEP) is a common and serious obstetric complication with unclear pathogenesis. This study aims to use single-cell RNA sequencing (scRNA-seq) to analyze immune cell composition and functional changes in i…

The endometrial receptive status is critical for a successful embryo implantation, but it only last for a short period of time, and the window of implantation (WOI) of each woman changes individually, which will lead to poor outcomes of ass…

STUDY QUESTION: What molecular mechanisms underlie the decline in ovarian reserve as the number and quality of oocytes decrease in patients with ovarian endometriomas (OEM)? SUMMARY ANSWER: Elevated expression of the let-7 micro(mi)RNAs in…