Drug design, development and therapy

ObjectiveTo compare the postoperative analgesic efficacy of oliceridine versus sufentanil in patients undergoing total laparoscopy hysterectomy.MethodsIn this double-blind, randomized controlled trial, 80 patients scheduled for elective tot…

PURPOSE: Regarding anesthesia management for high-intensity focused ultrasound (HIFU) treatment of uterine adenomyosis, existing research is limited. While considered non-invasive, HIFU ablation carries risks such as thermal injury to adjac…

BACKGROUND: Endometriosis is a chronic, oestrogen-dependent inflammatory disorder associated with elevated systemic oxidative stress. Current medical therapies are limited by significant side effects and high recurrence rates, underscoring …

Alopecia areata (AA) is a common autoimmune disorder characterized by non-scarring hair loss. While traditionally viewed as a T-cell-mediated disease, recent advances have elucidated the central role of the Janus kinase/signal transducer an…

Polygonatum odoratum (Mill.) Druce (Angular Solomon's seal) is a medicinal and edible plant belonging to the Asparagaceae family. Phytochemical investigations have revealed its diverse chemical constituents. This review systematically summa…

OBJECTIVE: To investigate the effects of Shaofu Zhuyu Decoction on decidualization and the expression of progesterone receptor-β (PR-β) and heterogeneous nuclear ribonucleoprotein L (HNRNPL) in a mouse model of endometriosis. METHODS: An e…

Goserelin is a gonadotropin-releasing hormone (GnRH) agonist with a long history of clinical application and well-established efficacy and safety profile. Its mechanism of action centers on sustained GnRH receptor desensitization, leading t…

Endometriosis (EMs) is a chronic neuroinflammatory disorder prevalent in women of reproductive age characterized by heterogeneous clinical manifestations, while conventional Western therapies are limited by obvious adverse reactions and uns…

BackgroundPatients undergoing total laparoscopic hysterectomy (TLH) commonly experience postoperative pain and are at relatively high risk of postoperative nausea and vomiting (PONV). Tegileridine is a recently developed biased μ-opioid rec…

PurposeThe prevalence of hyperuricemia has been increasing worldwide. Most studies have focused on the influences of hyperuricemia on kidney damage and cardiovascular disease. However, the impacts of hyperuricemia on the liver remain unclea…

PurposeTo investigate possible differences in cumulative live birth rates (CLBRs) among three progestins medroxyprogesterone acetate (MPA), dydrogesterone (DYG), and Progesterone within the progestin-primed ovarian stimulation (PPOS) protoc…

[This corrects the article DOI: 10.2147/DDDT.S500129.].

Pyridine carboxylic acid isomers - picolinic acid, nicotinic acid, and isonicotinic acid - have historically resulted in a plethora of drugs against tuberculosis, cancer, diabetes, Alzheimer's, angina, dementia, depression, allergy, respira…

Background: Both intramural myomas and thin endometrium exert a detrimental influence on the outcomes of assisted reproductive technology (ART). The downregulation of gonadotropin releasing hormone agonists (GnRH-a) is regarded as an effect…

Histone lactylation, as a common post-translational modification (PTM), is crucial in diseases. Aberrant histone lactylation has been linked to disease pathogenesis, thus positioning it as a therapeutic target. This review summarizes the bi…

Foshou San (FSS), which is a traditional Chinese compound formula. So far, a variety of components have been isolated and identified from its complex composition. These findings endow it with diverse pharmacological activities. According to…

BackgroundOverweight and obesity are link to impaired endometrial receptivity and decreased pregnancy success in frozen-thawed embryo transfer (FET) cycles. Depot gonadotropin-releasing hormone agonist (GnRH-a) pretreatment before hormone r…

PURPOSE: To test the expression profile of transient receptor potential channels (TRPs) in adenomyosis patients and evaluate the effects of primidone on tamoxifen-induced adenomyosis mice. PATIENTS AND METHODS: This study included in vivo …

PurposeTo explore the postoperative opioid-sparing effect and incidence of adverse events of different dosages of intraoperative esketamine administration in patients undergoing laparoscopic gynecological surgery.Patients and methodsPatient…

Palmitoylethanolamide (PEA) has attracted increasing attention from researchers as an endogenous lipid mediator. It exhibits a unique mechanism of action in alleviating pain, controlling inflammation, and providing neuroprotection. It prima…

Lactylation, a lactate-derived post-translational modification, emerges as a master metabolic regulator of resistance to regulated cell death (RCD) across pathologies including cancer, inflammatory disorders, and degenerative diseases. By d…

PurposeProgestin-primed ovarian stimulation (PPOS) has been widely employed in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles. In recent years, letrozole (LE) combined with medroxyprogesterone acetate (MPA) has be…

INTRODUCTION: In traditional Chinese medicine texts, Xuanyu Tongjing Decoction (XYTJD) is a prescribed remedy for premenstrual belly pain and dysmenorrhea. It is currently routinely used to treat ovarian endometriosis (OEM) with good outcom…

PurposeThe purpose of this study was to compare the efficacy of Follitropin alpha (Gonal-F) and Follitropin beta (Puregon) on cumulative live birth rate (CLBR), defined as the percentage of the number of patients who delivered for the first…