Yi Zhang

To investigate the expressions of miR23b and Sp1 in ovarian endometriosis and their clinic significance.
 Methods: qPCR was used to detect the expression of miR23b and Sp1 mRNA in paired ectopic/eutopic and normal endometrium. Immunohistoch…

In this study, we investigated the expression of interleukin 35 (IL-35) and its receptors in endometriosis, analyzed the function of IL-35 in primary culture model of endometrial stromal cells (ESCs), and evaluated their clinicapathological…

Objective To observe the clinical effect of letrozole combined with metformin on endometriosis. Methods One hundred and twelve cases of endometriosis from October 2013 to November 2014 were randomly divided into control group and tre…

STUDY OBJECTIVE: To evaluate the safety and efficacy of a new crosslinked hyaluronan (NCH) gel in reducing postoperative adhesions. DESIGN: Randomized controlled trial (Canadian Task Force classification I). SETTINGS: Seven departments of…

OBJECTIVE: To examine the expression of G protein-coupled estrogen receptor (GPER) and Gankyrin in ovarian endometriosis (OEM) and to evaluate its clinicopathological significance. METHODS: Immunohistochemistry was conducted to determine t…

OBJECTIVE: The aim of this study was to examine the expression of G protein-coupled estrogen receptor (GPER) and Gankyrin in ovarian endometriosis, analyze their clinicopathological significance, and investigate their correlation. METHODS:…

OBJECTIVE: To explore the advantage, feasibility and safety of modified approach to difficult vaginal hysterectomy and provide scientific rationales for expanding its indications. METHODS: A retrospective study was conducted for 237 patien…

OBJECTIVE: To compare the clinical effect of Chinese medicine (CM) and Western medicine (WM) for controlling the recurrence of pelvic endometriosis after a conservative operation. METHODS: The study was a multi-center, randomized, parallel…

OBJECTIVE: The purpose of this study is to investigate the potential genetic alterations at DNA level in patients with ovarian endometriosis by high-resolution array-based comparative genomic hybridization (array-CGH) analysis. METHODS: Fo…

Objective:To explore the application value of transvaginal hydrolaparoscopy(THL) in diagnosis of infertility.Methods:150 infertile cases who had visited outpatient department of the institute from May 2009 to October 2010 were selected,then…

Interleukin-16 (IL-16), a proinflammatory cytokine, plays a pivotal role in inflammatory diseases as well as in the pathogenesis of endometriosis. The aim of this study was to evaluate the association of IL-16 gene polymorphisms with the ri…

Objective:To investigate the single nucleotide polymorphisms of macrophage migration inhibitory factors(MIF)-173 in the endometriosis(EMs) and non-endometriosis(non-Ems) patients,also explore the association of MIF-173(G/C) and the suscepti…

【Objective】To investigate the surgical technique and analyse clinical outcome of laparoscopic clinical operation to cure ovarian endometriomas. 【Methods】The clinical data of 488 cases of ovarian endometriomas underwent laparoscopic operatio…

Objective To investigate the expression of 5-lipoxygenase (5-LOX) in endometriosis and analyze the relationship of 5-LOX and angionesis in endometriosis. Methods Immunochemical method was used to determine the expression of 5-LOX, VEGF, and…

Endometriosis is the presence of endometrial glands and stroma outside the endometrial cavity and is the most common known cause of pelvic pain．The number of women being diagnosed with the disease is increasing，afflicting about 7-10％of wome…

Objective To explore the role of TGF-βand TGIF in the pathogenesis of endometriosis. Methods The expression of TGF-β and TGIF was detected by immunohistochemistry method in the ectopic and eutopic endometrium of 30 cases with endometriosis …

OBJECTIVE: To investigate the clinical efficacy of Tiaomian Huayu Decoction (THD) in treating patients with endometriosis. METHODS: Patients in the treated group were administered with THD, those in the control group were given provera. T-…

OBJECTIVE: The objective was to investigate the expression of heparanase (Hpa) and angiopoietin-2 (Ang-2) in endometriosis. STUDY DESIGN: In ectopic and eutopic endometrium of patients undergoing laparoscopy for endometriosis (n=86) and in…

OBJECTIVE: To investigate the relationship between heparanase (Hpa) and angiopoietin-2 (Ang-2) gene expression and the development of endometriosis (EM). METHODS: Expression of Hpa gene and Ang-2 mRNA in the eutopic and ectopic endometrium…

目的 探讨乙酰肝素酶(Hpa)和促血管生成素2(Ang-2)基因在子宫内膜异位症(内异症)发生、发展中的作用.方法采用逆转录PCR(RT-PCR)技术,检测86例内异症患者(内异症组,其中Ⅰ～Ⅱ期内异症患者25例,Ⅲ～Ⅳ期内异症患者61例)的异位和在位内膜组织及30例非内异症患者(对照组)的子宫内膜组织中Hpa mRNA和Ang-2 mRNA表达.结果(1)内异症组异位和在位内膜组织中,Hpa mRNA阳性表达率分别为62%(53/86)和55%(47/86),两者比较,差异…

OBJECTIVE: Adenomyosis is a benign gynecological disease, characterized by the malignant biological behaviors of invasion and metastasis. ILK plays an important role in intercellular adhesion and triggers the process of EMT. In this study, …