Progress on the cause and pathogenesis of endometriosis

Endometriosis is the presence of endometrial glands and stroma outside the endometrial cavity and is the most common known cause of pelvic pain．The number of women being diagnosed with the disease is increasing，afflicting about 7-10％of women worldwide．It is one of the most frequent benign gynaecological diseases．However，why is it taken bad so widespread，and what form? Little is known about the pathogenetic processes leading to the development and maintenance of this disease and the currently available therapeutic strategies are unsatisfactory．There are many theories for the development of the disease endometriosis．Including the planting theory．the coelomic epithel ial metaplasia theory and the inductive theory．The most Wjdely accepted theory is the theory what is postulated the endometriosis is a result of retrograde menstruation．The modern interpretation of the theory of reflux menstruation holds that women destined to develop endometriosiS have a deficient immune system，which cannot defend against regurgitated endometrial cells．New findings on genetics，immune modulation，and secreted products of endometriotic lesions of affected women have given insight into the aetiology of this disorder．The goal of this article is to review the most recent advancements in the etiology and pathogenesis． Key words: Endometriosis; Etiology; Review