Naoki Terakawa

No ORCID on file · 77 papers in corpus · active 1986-2021

Study types

  • article 62
  • review 6
  • other 3
  • book-chapter 2
  • case-report 1

Condition tags

  • endometriosis 56
  • endometrioma 9
  • infertility 6
  • chronic_pelvic_pain 4
  • dysmenorrhea 3
  • dyspareunia 3
  • adenomyosis 1
rct 2021
BMC women's health ·doi:10.1186/s12905-021-01393-3

BACKGROUND: Relugolix is a once-daily, oral, nonpeptide, gonadotropin-releasing hormone receptor antagonist. The aim of this study was to evaluate safety of relugolix over 24 weeks in women with endometriosis-associated pain. METHODS: This…

article 2020
Fertility and sterility ·doi:10.1016/j.fertnstert.2020.07.055

ObjectiveTo evaluate the efficacy and safety of three dose levels of relugolix, a gonadotropin-releasing hormone receptor antagonist, compared with placebo and leuprorelin in women with endometriosis-associated pain.DesignPhase 2, multicent…

article 2017
·doi:10.1530/endoabs.49.gp134

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

article 2016
·doi:10.1016/j.fertnstert.2016.07.781
article 2015
·doi:10.1016/j.fertnstert.2015.07.509
article 2014
Gynecologic and obstetric investigation ·doi:10.1159/000357819

OBJECTIVE: To investigate the clinical features of patients in Japan with malignant transformation of ovarian endometrioma. PATIENTS: Thirty-three patients diagnosed with ovarian cancer presumably arising from endometrioma were recruited re…

article 2014
·doi:10.1016/j.fertnstert.2014.07.171
article 2014
·doi:10.1016/j.fertnstert.2014.07.039
review 2013
Frontiers in bioscience (Elite edition) ·doi:10.2741/e669

Endometriosis is an estrogen-dependent inflammatory disease. In endometriotic tissues, a high-estrogen environment associated with up-regulation of the aromatase gene has been well documented. There is accumulating evidence supporting a con…

article 2013
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society ·doi:10.1097/igc.0b013e31828f38c4

ObjectiveThe objective of this study was to determine the genes that may be associated with malignant transformation of ovarian endometrioma.MethodsEndometriotic epithelial cells were isolated from tissues derived from chocolate cyst lining…

article 2012
Gynecologic and obstetric investigation ·doi:10.1159/000343748

AIMS: We investigated the potential of gonadotropin-releasing hormone (GnRH) agonists and GnRH antagonists to inhibit cell proliferation in endometriotic and endometrial stromal cells. METHODS: Twenty patients with ovarian endometriomas and…

article 2012
·doi:10.1016/j.fertnstert.2012.07.340
article 2012
·doi:10.1016/j.fertnstert.2012.07.339
review 2012
Frontiers in bioscience (Scholar edition) ·doi:10.2741/s327

The nuclear factor kappaB (NF-kappaB) is a ubiquitously expressed transcription factor playing vital roles in innate immunity and other processes involving cellular survival, proliferation, and differentiation. This review highlights the im…

book-chapter 2011
·doi:10.1210/endo-meetings.2011.part3.p25.p3-172
book-chapter 2011
·doi:10.1210/endo-meetings.2011.part3.p25.p3-181
article 2011
·doi:10.1016/j.fertnstert.2011.07.534
article 2010
·doi:10.1016/j.fertnstert.2010.07.779
article 2010
·doi:10.1016/j.fertnstert.2010.09.046
review 2010
Frontiers in bioscience (Elite edition) ·doi:10.2741/e277

Apoptosis is a distinctive form of programmed cell death resulting in the efficient elimination of cells without eliciting an inflammatory response. Endometriosis is characterized by the presence of endometrial cells with capacity to avoid …

article 2010
Fertility and sterility ·doi:10.1016/j.fertnstert.2010.06.024

ObjectiveTo search for the demethylated cytosine-phosphate-guanine (CpG) islands within the aromatase gene in stromal cells derived from endometriotic chocolate cysts.DesignProspective study.SettingDepartment of Obstetrics and Gynecology an…

article 2009
Fertility and sterility ·doi:10.1016/j.fertnstert.2009.06.042

Lipopolysaccharide-enhanced cyclooxygenase 2 (COX-2) expression and prostaglandin E2 (PGE2) production were compared in endometriotic stromal cells (ESCs) and eutopic endometrial stromal cells. Lipopolysaccharide promotes the proliferation …

other 2009
Journal of Obstetrics and Gynaecology Research ·doi:10.1111/j.1447-0756.2009.01076.x

AIM: To investigate the safety and efficacy of 52 weeks of dienogest treatment in patients with endometriosis. METHODS: One hundred and thirty-five patients with endometriosis received 2 mg of dienogest orally each day for 52 weeks. Advers…

article 2009
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/j.1600-0897.2009.00691.x

PROBLEM: We previously reported that lipopolysaccharide (LPS)-promoted endometriotic stromal cell (ESC) proliferation by inducing TNFalpha production. The aim of this study was to investigate the efficacy of TNFalpha gene silencing on LPS-t…

article 2009
·doi:10.1016/j.fertnstert.2009.07.1102