Wu Y

Adenomyosis, characterized by the invasion of endometrial cells into the myometrium, may disrupt immune homeostasis within the eutopic endometrium, thereby impairing endometrial receptivity. This retrospective case-control study aimed to in…

BACKGROUND: Ultrasound-based deep learning (DL) models for the precise diagnosis of endometrial cancer are insufficient. Our aim is to develop and validate an automatic multi-modal ultrasound DL prediction model for the accurate identificat…

BACKGROUND: Spontaneous ovarian endometrioma rupture typically presents with acute abdominal pain, a condition often complicated by tissue edema and pelvic adhesions that increase surgical difficulty. This study aims to evaluate the impact …

Iron overload induces cellular stress and is implicated in diverse pathological conditions. Nevertheless, the epigenetic mechanisms governing mammalian cellular responses to iron overload remain poorly characterized. Using multi-omics profi…

Endometriosis is a chronic estrogen-dependent disorder affecting up to 10% of women of reproductive age, and the absence of reliable noninvasive diagnostic tools contributes to delayed diagnosis and disease progression. To identify potentia…

Upon exposure to biofluids, engineered nanoparticles (NPs) spontaneously form reproducible biomolecular coronas via selective diverse biomolecule adsorption. The corona characterization of metabolites poses greater analytical challenges tha…

IntroductionGraves' disease (GD) is a classical autoimmune disorder caused by interactions between genetic susceptibility and immune dysregulation. However, the transcriptomic mechanisms underlying disease relapse and remission, particularl…

BACKGROUND: Optimal endometrial thickness and receptivity, precisely regulated by steroid hormones, are critical determinants for successful embryo implantation. Thin endometrium is a major cause of female infertility, yet its pathogenesis …

ObjectivesThis study aimed to develop a multimodal predictive model that integrates clinical data, radiomics, and three-dimensional deep learning to forecast acute respiratory distress syndrome in patients with acute pancreatitis.MethodsThi…

BACKGROUND: Endometriosis (EMs) is an estrogen-dependent chronic inflammatory disease, and its pathogenesis remains unclear. Although the placenta is an organ with tumor-like characteristics, its development, including its invasive function…

BackgroundAbdominal pregnancy refers to the implantation of a fertilized egg in the abdominal cavity outside of the uterus, fallopian tubes, and ovaries; splenic pregnancy is a rare type of abdominal pregnancy.Case presentationOur patient w…

PURPOSE: Adenomyosis (AM) with dysmenorrhea (AMD) is a global public health concern that may involve abnormal brain function and heightened vulnerability to anxiety and depression. This study aimed to investigate static and dynamic regional…

BackgroundHyperthyroidism adversely impacts female reproduction, yet its association with in vitro fertilization (IVF) outcomes remains controversial. It remains unknown whether ovarian function recovers upon achieving euthyroidism. We comp…

Pregnant women undergoing assisted reproductive technology (ART) have an increased risk of gestational diabetes mellitus (GDM), potentially linked to altered immune regulation, but the underlying circulating immune features remain unclear. …

Endometriosis is a chronic gynecological disorder defined by the growth of endometrial-like tissue outside the uterus, driven by estrogen-dependent inflammation and progressive fibrosis. According to available data, remodeling and persisten…

Haochan Wu,1,* Fangfang Shan,1,* Mengmeng Ye,1 Hui Zhou,1,2 Jie Jiao,3 Zhaoxia Zhong,4 Yibo Wu1,2 1Human Reproductive Medicine Center, Affiliated Hospital of Jiangnan University, Wuxi, People’s Republic of China; 2Human Genetic and …

The microbiota of the female genital tract is crucial for reproductive health. This study aims to investigate the impact of the lower genital tract microbiota on in vitro fertilization and frozen embryo transfer (IVF-FET) outcomes. This stu…

Nab-paclitaxel plus gemcitabine (AG) is the standard first-line chemotherapy for advanced or metastatic pancreatic ductal adenocarcinoma and has limited efficacy. This phase 1b/2 study aimed to evaluate SHR-1701 (an anti-PD-L1/TGF-βRII fusi…

PurposeARID1A, encoding a component of the switch/sucrose nonfermentable complex, is frequently mutated in urothelial carcinoma. However, its specific impacts on clinical outcomes and CD8+ T-cell functions in urothelial carcinoma remain poo…

PurposeThe International Federation of Gynecology and Obstetric (FIGO) stage is critical to guiding the treatments of ovarian cancer (OC). We tried to develop a model to predict the FIGO stage of OC through machine learning algorithms with …

OBJECTIVES: Obesity and endometriosis are intricately linked. The body mass index (BMI) is commonly used as an indicator of obesity, but it has limitations. The visceral adiposity index (VAI) is a novel, low-cost composite index that reflec…

BackgroundInsulin resistance (IR) is a common pathophysiologic feature in patients with polycystic ovary syndrome (PCOS). However, there have been no studies investigating the association of IR surrogates with pregnancy outcomes in women wi…

BackgroundFew previous studies have addressed the impact of COVID-19 infection status on assisted reproductive technology outcomes. The purpose of this study was to assess whether COVID-19 infection affects ovulation induction outcomes and …

OBJECTIVE: To investigate the clinical features of bladder endometriosis and factors associated with urinary symptoms, pregnancy outcomes, and long-term effects of symptom relief and recurrence. DESIGN: A single-center retrospective cohort…