Progressively enlarged Caesarean section scar endometriosis during pregnancy: case report and literature review

Abdominal wall endometriosis is a rare form of endometriosis, with a reported incidence of 0.03% to 0.4%.1 Most cases occur near a CS scar. Previous studies have described changes in pelvic endometriosis during pregnancy,2 3 but there is limited literature describing the progression and management of AWE during pregnancy. In this case, the patient experienced significant enlargement of scar endometriosis during pregnancy, indicating that AWE, similar to pelvic endometriotic lesions, may also gradually enlarge during gestation. The first-line treatment for AWE is surgical excision of the mass, which is typically performed in the non-pregnant period. As the lesion is often closely related to a previous CS scar, simultaneous excision may significantly increase the complexity of CS. In this case, the lesion was dissected along its margin during CS. Our retrospective study demonstrated that among 367 patients who underwent margin-based excision, the recurrence rate was 3.3%,4 comparable to or lower than rates reported in previous studies.5 6 This suggests that excision along the lesion margin is sufficient and does not increase the risk of recurrence. After thorough assessment, excision during CS may be considered if the lesion is small and demonstrates minimal depth of invasion. Given the potential for lesion enlargement and the challenges of abdominal wall reconstruction during pregnancy, timely surgical intervention is particularly advisable for patients planning future pregnancies. Preoperative evaluation is also crucial. Our previous research classified patients into three types according to the depth of lesion invasion.4 This patient could be clinically classified as Type I AWE. Given the minimal muscular invasion and stretching of the abdominal wall due to the gravid uterus, primary closure without mesh placement was feasible. This highlights the importance of comprehensive preoperative assessment to guide the choice of surgical approach and anticipate operative complexity. Decidualisation of endometriosis can occur under the influence of high progesterone levels.7 Since Pellegrini8 first described this condition in 1982, only nine cases of decidualised AWE have been reported.2 8 9 10 11 12 13 14 15 In these cases, the mean age was 28.6 ± 5.8 years, and the mean latency from first CS to mass presentation was 29.6 ± 24.2 months. The depth of invasion in these patients differs from that in non-pregnant patients. Our previous research4 showed that in non-pregnant patients, AWE lesions most commonly invade the rectus abdominis muscle. In contrast, existing literature indicates that in pregnant patients, lesions were confined to the subcutaneous and adipose layers, with only one case showing invasion of the rectus abdominis. Enlargement during pregnancy was reported in two patients, with the maximum diameter reaching 3 cm.9 10 Six patients underwent lesion excision during CS,2 8 10 11 12 13 and one underwent elective surgery after CS.14 In our case, the patient experienced rapid enlargement of the AWE during pregnancy and imaging raised a suspicion of malignancy. This suggests that decidualised AWE during pregnancy may present with features mimicking malignancy. Histopathological examination in our patient revealed a positive progesterone receptor expression and absence of oestrogen receptor expression, indicating that the intrinsic biological characteristics of the lesion may have contributed to its abnormal growth. Limited treatment options during pregnancy pose additional risks to maternal and fetal safety. Therefore, in patients with AWE who wish to conceive in the future, surgery should ideally be performed before pregnancy. Author contributions Concept or design: Y Wu, J Leng, Y Dai. Acquisition of data: Y Wu, J Shi, X Li.. Analysis or interpretation of data: Y Li.. Drafting of the manuscript: Y Wu.. Critical revision of the manuscript for important intellectual content: J Leng, Y Dai. Acquisition of data: Y Wu, J Shi, X Li.. Analysis or interpretation of data: Y Li.. Drafting of the manuscript: Y Wu.. Critical revision of the manuscript for important intellectual content: J Leng, Y Dai. All authors had full access to the data, contributed to the study, approved the final version for publication, and take responsibility for its accuracy and integrity. Conflicts of interest All authors have disclosed no conflicts of interest. Funding/support This study was supported by the National Key Research and Development Program Project (Ref No.: 2022YFC2704000) and the National Natural Science Foundation of China (Ref No.82071628). The funders had no role in the study design, data collection/analysis/interpretation, or manuscript preparation. Ethics approval This study was approved by the Institutional Review Board of Peking Union Medical College Hospital, China (Ref No.: K23N4099). Informed consent was obtained from the patient for all treatments and procedures, and for publication of the case report with the accompanying clinical images.

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