Lin J

OBJECTIVE: To investigate the expression of suppressor of cytokine signaling(SOCS)-3 and caspase-3 and their correlative significance in endometriosis. METHODS: Immunohistochemical EnVision method was used to detect the SOCS-3 and caspase-3…

This study investigates the influence of ovarian endometrioma on expression of steroid receptor RNA activator (SRA), estrogen receptors (ERs), vascular endothelial growth factor (VEGF), and thrombospondin 1 (TSP-1) in the surrounding ovaria…

Deep infiltrating endometriosis (DIE) is typically characterized by multifocal locations. It has been shown that CCR1, combined highly with RANTES, contributes to the enhanced recruitment of inflammatory cells at endometriotic sites. As an …

Aquaporin (AQP)-dependent cell migration has broad implications in angiogenesis, tumor metastasis, wound healing, glial scarring and other events requiring cell movement. There are 13 isoforms of AQP (0-12) that have been identified in mamm…

Ezrin is a member of the ezrin-radixin-moesin (ERM) family of membrane-cytoskeletal linkage proteins. It is important for maintenance of cell shape, adhesion, migration and division. The overexpression of ezrin in some tumours is associated…

Endometriosis is a common, chronic gynaecological disease affecting up to 10% of women in their reproductive years. Its aetiology still remains unclear, but evidence indicates genetic factors play a role. We previously identified a region o…

OBJECTIVE: To evaluate the effects of PRL-3 siRNA (small interfering RNA) on the migration of endometriotic stromal cells. METHODS: Primary endometriotic stromal cells were cultured in vitro. Then PRL-3 (phosphatase of regenerating liver-3…

Endometriosis is a common gynecological disease associated with pelvic pain and subfertility. We conducted a genome-wide association study (GWAS) in 3,194 individuals with surgically confirmed endometriosis (cases) and 7,060 controls from A…

Longer duration of reproductive years of life and thus greater exposure to endogenous estrogen may be associated with a lower risk of age-related diseases in women. The present study examined the relationship between estimated endogenous es…

Endometriosis is a common gynecological disease associated with pelvic pain and subfertility. We conducted a genome-wide association study (GWAS) in 3,194 individuals with surgically confirmed endometriosis (cases) and 7,060 controls from A…

OBJECTIVE: To determine whether nerve fibers can be detected in the endometrium and myometrium in women with painful uterine fibroids and adenomyosis. DESIGN: A retrospective immunohistochemical study. SETTING: An academic training hospit…

ObjectiveTo investigate the expression of phosphatase of regenerating liver-3 (PRL-3) in ectopic, eutopic, and normal endometria and explore its relationship with endometriosis.DesignA clinical retrospective and molecular study.SettingDepar…

OBJECTIVE: To investigate nerve fibers distribution in endometrium of adenomyosis and their relationship with dysmenorrhea. METHODS: Endometrial tissue was sampled from 74 hysterectomy specimens including 32 cases with adenomyosis and 42 ca…

To determine whether nerve fibers in the functional layer endometrium are caused by an endometriosis itself or a common symptom of pain, endometrial tissues from 30 women with endometriosis, 40 women with adenomyosis, 41 women with uterine …

Extracting DNA from formalin-fixed and paraffin-embedded (FFPE) tissue remains a challenge, despite numerous attempts to develop a more effective method. Polymerase chain reaction (PCR) success rates with DNA extracted using current methods…

ObjectiveTo investigate the expression of aquaporin (AQP) in eutopic and ectopic endometrial tissues from women with endometriomas.DesignControlled laboratory research.SettingHospital-based unit for gynecology and obstetrics and research la…

OBJECTIVE: To evaluate the association between the susceptibility of endometriosis (EMS) and the gene polymorphism of tumor necrosis factor (TNF) in Chinese Han population. METHODS: Peripheral blood samples were collected from 76 EMS patien…

BACKGROUND: Danazol, a synthetic steroid with antigonadotrophic properties, has been widely used for the treatment of endometriosis and adenomyosis. However, the local application of danazol to the uterus to treat adenomyosis is controversi…

OBJECTIVE: To determine the level of interleukin-1 receptor antagonist (IL-1ra) in peritoneal fluid (PF) and serum in patients with endometriosis. DESIGN: A prospective analytical study. SETTING: University-affiliated obstetrics and gynec…

Endometriosis is a common, benign, oestrogen-dependent, gynaecological disorder that occurs in women in their reproductive years. Although it has been studied for many years, the aetiology and pathophysiology of endometriosis are still uncl…

Endometriosis is a common, benign, oestrogen-dependent, gynaecological disorder that occurs in women in their reproductive years. Although it has been studied for many years, the aetiology and pathophysiology of endometriosis are still uncl…

Endometriosis is a common, benign, oestrogen-dependent, gynaecological disorder that occurs in women in their reproductive years. Although it has been studied for many years, the aetiology and pathophysiology of endometriosis are still uncl…

Endometriosis is a common, benign, oestrogen-dependent, gynaecological disorder that occurs in women in their reproductive years. Although it has been studied for many years, the aetiology and pathophysiology of endometriosis are still uncl…

Endometriosis is a common, benign, oestrogen-dependent, gynaecological disorder that occurs in women in their reproductive years. Although it has been studied for many years, the aetiology and pathophysiology of endometriosis are still uncl…

Endometriosis is a common, benign, oestrogen-dependent, gynaecological disorder that occurs in women in their reproductive years. Although it has been studied for many years, the aetiology and pathophysiology of endometriosis are still uncl…