Immunohistochemical detection of aquaporin expression in eutopic and ectopic endometria from women with endometriomas

Xiu-xiu Jiang, Jiang XX, Xiuxiu Jiang, Riu-Jin Wu, Wu RJ, Kaihong Xu, Kai-Hong Xu, Xu KH, Cai-yun Zhou, Caiyun Zhou, Zhou CY, Xiao-Yan Guo, Xiaoyan Guo, Guo XY, Sun YL, Ya-Li Sun, Yali Sun, Jun Lin, Lin J
Fertility and sterility · 2009 · vol. 94(4) , pp. 1229–1234 · doi:10.1016/j.fertnstert.2009.08.053 · PMID:19931078 · W1967894184
article OA: bronze CC0 ⤵ 8 in-corpus citations
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This study examined aquaporin expression in eutopic and ectopic endometrial tissues from women diagnosed with endometriomas.

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Abstract

ObjectiveTo investigate the expression of aquaporin (AQP) in eutopic and ectopic endometrial tissues from women with endometriomas.DesignControlled laboratory research.SettingHospital-based unit for gynecology and obstetrics and research laboratories.Patient(s)Premenopausal women undergoing laparoscopy for endometriomas.Intervention(s)Endometrial biopsy samples obtained from 70 women with endometriomas.Main outcome measure(s)Semiquantitative analysis by immunohistochemistry.Result(s)Aquaporins 2, 5, and 8 were mainly located in luminal and glandular epithelia. The frequency of positive immunostaining for aquaporins 2, 5, and 8 decreased in ectopic compared with eutopic endometria. Aquaporins 2, 5, and 8 were found at a low frequency in the endometria in early proliferative phases but at a higher frequency in late proliferative and secretory phases. There were no significant differences in the menstrual cycle of the proliferative phase and secretory phase in the two groups.Conclusion(s)Aquaporins 2, 5, and 8 were expressed with greater frequency in eutopic endometrial cells than inectopic endometrial cells, suggesting that eutopic endometrial cells have stronger migration activity than ectopic endometrial cells in women with endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Aquaporins Choristoma Endometriosis Endometrium Peritoneal Diseases Adult Aquaporins Choristoma Choristoma Endometriosis Endometriosis Endometrium Endometrium Female Humans Immunohistochemistry Menstrual Cycle Menstrual Cycle Menstrual Cycle Middle Aged

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