Ariane Germeyer

BACKGROUND: Endometriosis is a gynecological condition which often causes chronic or recurrent pelvic pain (CPP). The disease can thereby impose a significant burden on affected individuals and their romantic relationships. Existing researc…

Abstract Study question What are the metabolome differences between the serum of patients with endometriosis and control subjects? What metabolic traits are characteristic of peritoneal and/or ovarian endometriosis? Summary answer Endometri…

BACKGROUND: Endometriosis is a frequent disease in women of reproductive age in which the endometrium occurs outside the uterine cavity. Multimodal treatment approaches are necessary due to loss of quality of life and the chronic nature of …

PURPOSE: Endometriosis and infertility are associated with impaired partnership and sexuality of the patients, but also of their male partners. Also, endometriosis is one of the most common causes of infertility, resulting in a large overla…

BACKGROUND: The pathogenesis of deep infiltrating endometriosis (DIE) is poorly understood. It is considered a benign disease but has histologic features of malignancy, such as local invasion or gene mutations. Moreover, it is not clear whe…

Abstract Study question How does the gene expression profile of epithelium cells differ between deep infiltrating endometriosis (DIE) and adenomyosis (FA)? Summary answer The gene expression of epithelial cells from DIE reveals a significan…

PURPOSE: This study attempted at identifying the main parameters influencing the outcome of frozen embryo transfers. METHODS: This is a single-center retrospective cohort study of 830 frozen-embryo-transfer cycles performed at a German uni…

Abstract Purpose Endometriosis and infertility are associated with impaired partnership and sexuality of the patients, but also of their male partners. The aim of this study was to determine the association of different predictors of partne…

Zielsetzung Soziale Einflussfaktoren wie Unterstützung, aber auch Stress, können das Schmerzerleben entscheidend beeinflussen, wie Forschung z.B. bei chronischen Rückenschmerzen zeigen konnte. Gleichzeitig unterscheidet sich die neurale Sch…

BACKGROUND: Endometriosis is often associated with severe dysmenorrhea, pelvic pain and dyspareunia and has a high impact on daily life as well as sexuality. Quality of partnership positively influences the course of various diseases and ab…

Endometriosis is supposed to affect only women in their reproductive years, but endometriotic lesions can reactivate in menopause and cause significant complaints in these patients. Altered needs and co-morbidities of the women request a di…

In order to improve ART outcome, non-invasive embryo assessment is gaining more and more attention. Therefore, the aim of this study is to determine the consecutive implantation potential via the secretome between blastocysts with or withou…

Einleitung: Die Endometriose ist mit ihren vielseitigen Erscheinungsformen ein Chamäleon unter den Erkrankungen. Eine eindeutige Ätiologie ist bislang nicht bekannt und die Heterogenität der klinischen Symptomatik erschwert die frühzeitige …

Zielsetzung 10-15 % aller Frauen im reproduktiven Alter sind von Endometriose betroffen. Dennoch sind die molekularen Mechanismen sowie die Pathogenese nicht vollständig geklärt. Das Ziel der Studie war, die unterschiedlichen Stadien der Er…

PURPOSE: Endometriosis (EM) is a common gynecological disease affecting 10-15% of women of reproductive age. However, molecular mechanisms and pathogenesis are still not completely understood. Furthermore, due to the absence of a reliable c…

It is known that endometriosis is associated with an increased risk for certain forms of ovarian cancer. However it is unknown, which kind of endometriosis is associated with ovarian cancer and furthermore, if endometriosis is associated wi…

A 27-year-old Caucasian (gravida 2 para 1) presented in week 16 of her twin pregnancy with worsening of hyperandrogenic symptoms. In week 17, she developed an acute abdomen due to a twisted, incarcerated right ovary, which was surgically re…

Die Implantation ist ein bisher nicht vollständig verstandener Prozess, der zellbiologisch ein Paradoxon darstellt. Zum einen ist der Embryo zu 50% paternal und somit teilweise immunologisch fremd, und zum anderen sind das Endometrium und d…

Endometriosis is clinically associated with pelvic pain and infertility, with implantation failure strongly suggested as an underlying cause for the observed infertility. Eutopic endometrium of women with endometriosis provides a unique exp…