Cancers in Patients with Endometriosis

This retrospective study used the International Endometriosis Evaluation Program (IEEP) to characterize the frequencies of cancer diagnoses recorded as comorbidities among 4,539 endometriosis patients (after exclusions for missing surgical diagnosis, lesion location, or comorbidity documentation). Cancer prevalence was 2.4% overall, with the highest documented prevalence in patients with peritoneal endometriosis paired with adenomyosis (3.2%); endometrial cancer cases were concentrated in the adenomyosis group (4 of 5), and most ovarian cancer cases occurred among patients with ovarian endometriosis. The authors note a key limitation that the number of patients with cancer was small, leaving uncertainty despite observed differences between lesion/location groups. This paper is centrally about endometriosis — and specifically compares cancer comorbidity frequencies across endometriosis lesion types including adenomyosis-only, using IEEP registry data.

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