Hyperreaktive Luteome in der Schwangerschaft – Symptomatik und Komplikationen: Ein Fallbericht

Ariane Germeyer, Friedrich Kommoss, Thomas Strowitzki, Michael von Wolff
In: Gynäkologisch-geburtshilfliche Rundschau · 2009 · vol. 49(4) , pp. 331–334 · doi:10.1159/000301113 · PMID:20530950 · W2091653179
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A woman with hyperandrogenic symptoms in twin pregnancy underwent surgery for a twisted ovary, later diagnosed with recurrent hyperreactio luteinalis and developing preeclampsia, with symptoms resolving postpartum.

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Abstract

A 27-year-old Caucasian (gravida 2 para 1) presented in week 16 of her twin pregnancy with worsening of hyperandrogenic symptoms. In week 17, she developed an acute abdomen due to a twisted, incarcerated right ovary, which was surgically removed. Histological analysis revealed a diffuse steroid cell hyperplasia. Postsurgery testosterone levels fell temporarily within normal limits, diminishing the hyperandrogenic symptoms. Over time androgen levels rose again slowly above normal values with clinical worsening of hirsutism. In the 32nd week of gestation, a cesarean section of two healthy female infants was necessary due to the development of preeclampsia. An ovarian biopsy revealed again the picture of hyperreactio luteinalis. Postpartum peripheral hormone levels fell within normal limits and the hyperandrogenic symptoms subsided.

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chemicals 2
steroid testosterone

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