Chen X

BackgroundThin endometrium (TE) has been widely recognized as a critical cause of various obstetric and gynecological conditions. Although the role of stem cells in endometrial functions and their pathologies has been suggested, the identit…

Mesenchymal cells constitute the primary structural support elements within endometriotic lesions, yet their pivotal roles in endometriotic pathogenesis remain largely uncharted. This study aimed to construct a single-cell atlas of endometr…

Endometriosis (EMs) is a gynecological disorder characterized by chronic inflammation and an aberrant immune microenvironment. In this study, we integrated the GSE6364 dataset from the GEO database to identify differentially expressed genes…

BACKGROUND: Endometriosis-associated ovarian cancer (EAOC) mainly includes endometrioid ovarian cancer (ENOC) and clear cell ovarian cancer (CCOC). The Cancer Genome Atlas (TCGA) revealed four molecular subtypes of endometrial cancer (EC) i…

BackgroundChronic pancreatitis (CP) is characterized by significant pancreatic exocrine dysfunction, with limited targeting therapeutic strategies. It has been reported that DCHD can effectively alleviate pancreatic injury in chronic pancre…

PurposeProgestin-primed ovarian stimulation (PPOS) has been widely employed in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles. In recent years, letrozole (LE) combined with medroxyprogesterone acetate (MPA) has be…

OBJECTIVE: To evaluate the current treatment status and management deficiencies of adenomyosis in Luzhou, China. MATERIALS AND METHODS: A small-scale observational cross-sectional study of patients whose imaging suggests adenomyosis from J…

BackgroundDiet, lifestyle, and oxidative stress have been linked to female infertility, with the Oxidative Balance Score (OBS) serving as a comprehensive indicator of an individual's oxidative and antioxidant status. This study aims to inve…

RationaleUterine perforation complicated by incarcerated fallopian tube and cesarean scar pregnancy (CSP) constitutes an exceptionally rare and clinically challenging condition. The diagnostic dilemma arises from elevated β-hCG levels combi…

ObjectiveTricho-rhino-phalangeal syndrome-1 (TRPS1), an atypical GATA transcription factor, plays a critical role in diverse physiological and pathological processes and holds potential as a biomarker for diseases and targeted tumor therapi…

BackgroundThe process of in vitro fertilization-embryo transfer (IVF-ET) induces a maternal supraphysiological estradiol environment during embryo implantation and early development. Estrogen is crucial in modulating the colonization of mic…

RationaleDyspareunia is a common disease affecting the physical and mental health of individuals. There are several reasons for dyspareunia. It is essential to identify the causes of dyspareunia and to implement targeted treatments.Patient …

BackgroundUterine leiomyosarcoma(uLMS) is a rare malignant tumor with low clinical specificity and poor prognosis.There are many studies related to uLMS, however, there is still a lack of metrological analyses with generalization. This stud…

ObjectiveThe objective of this study was to evaluate the clinical efficacy of acupuncture combined with Chinese herbs versus Chinese herbs alone in treating uterine fibroids.MethodsA literature search of eight databases identified nine rand…

BackgroundDue to the limitations of clinical trials, some delayed and rare adverse events (AEs) may remain undetected, and safety information can be supplemented through post-market data analysis. This study aims to comprehensively analyze …

Aldo-Keto Reductase Family 1 Member C3 (AKR1C3), also known as type 5 17β-hydroxysteroid dehydrogenase (17β-HSD5) or prostaglandin F (PGF) synthase, functions as a pivotal enzyme in androgen biosynthesis. It catalyzes the conversion of weak…

Virulence factor genes (VFGs) play pivotal roles in bacterial infections and have been identified within the human gut microbiota. However, their involvement in chronic diseases remains poorly understood. Here, we establish an expanded VFG …

OBJECTIVE: The main purpose of the study was to explore the clinicopathological features and survival outcomes of patients with cervical cancer (CC) and adenomyosis and without the latter and to gain insight into the timely association betw…

ObjectiveVery few and conflicting data are available regarding the correlation between circulating carbohydrate antigen 19-9 (CA19-9) levels and diabetic kidney disease (DKD) and its components including albuminuria and a low estimated glom…

BackgroundPrimordial follicle activation is vital for the reproduction of women with advanced age and premature ovarian insufficiency (POI). But there is a lack of effective and safe therapeutic options to activate their primordial follicle…

BackgroundEvidence indicates that the risk of developing a secondary ovarian cancer (OC) is correlated with estrogen receptor (ER) status. However, the clinical significance of the relationship between ER-associated breast cancer (BC) and c…

Ceria nanoparticles (CeO2 NPs) have become popular materials in biomedical and industrial fields due to their potential applications in anti-oxidation, cancer therapy, photocatalytic degradation of pollutants, sensors, etc. Many methods, in…

Infertility is a prevalent problem among 10% of people within their reproductive years. Sometimes, even advanced treatment options like assisted reproduction technology have the potential to result in failed implantation. Because of the exp…

ObjectiveTo analyze the clinical characteristics of scar cancer ulcer wound of head and face, and to investigate its diagnosis and treatment.MethodsThe clinical data of 14 patients with head and facial scar cancer ulcer wounds who met the s…

ObjectiveThe present research aims to assess the factors that influence live birth outcomes following fresh embryo transfers using antagonist protocols in individuals diagnosed with polycystic ovary syndrome (PCOS). Furthermore, it seeks to…