SPP1 as a key modulator of M2 macrophage polarization promotes endometriosis progression via activation of the FAK/PI3K/AKT pathway: A bioinformatics and experimental study

Sijia Zhang, Yi Yang, Chen Zhang, Xiaoyao Chen, Fawei Li, Jiaoyue Li, Xi Cheng, Xiangtong Liu, Yanan Guo, Yanning Zhu, Changming Zhai, Xiaona Ma
International immunopharmacology · 2025 · vol. 166 , pp. 115563 · doi:10.1016/j.intimp.2025.115563 · PMID:40967048 · W4414273357
article OA: closed CC0
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

SPP1 was identified as a key modulator of M2 macrophage polarization, promoting endometriosis progression through activation of the FAK/PI3K/AKT pathway.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood

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References (51)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-06-02T00:31:05.662070+00:00
License: CC0 · commercial use OK