TCGA molecular subtypes in endometriosis-associated ovarian cancer: a systematic review and meta-analysis

Luxin Ye, Jiahui Chen, Wenwen Guo, Qian Zhao, Xianzhong Cheng, Xuening Wang, Xia Xu, Xiaoxiang Chen, Jing Ni
Annals of medicine · 2025 · vol. 57(1) , pp. 2583543 · doi:10.1080/07853890.2025.2583543 · PMID:41220042 · PMC12613302 · W4416125704
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This systematic review and meta-analysis investigated the distribution, staging, and prognostic characteristics of TCGA molecular subtypes in endometriosis-associated ovarian cancer and found similarities in prognosis between endometrioid and clear cell subtypes.

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Abstract

BACKGROUND: Endometriosis-associated ovarian cancer (EAOC) mainly includes endometrioid ovarian cancer (ENOC) and clear cell ovarian cancer (CCOC). The Cancer Genome Atlas (TCGA) revealed four molecular subtypes of endometrial cancer (EC) in 2013, which have been proven pivotal in the diagnostic, prognostic and therapeutic domains of EC. Existing evidence indicates that EC and EAOC molecular analysis have similar significance. This review aims to investigate the distribution, staging and prognostic characteristics of molecular subtypes in EAOC. METHODS: PubMed, Embase and Web of Science were systematically searched from January 2013 to December 2023 using predefined keywords. Patient characteristics, including stage and prognostic characteristics, were extracted from the selected studies. Data analysis was carried out using Stata 14MP. RESULTS: = 0.000). CONCLUSION: The TCGA subtypes of EC may exhibit similarities in prognosis between ENOC and CCOC.

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid

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References (45)

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