Liu X

ObjectiveTo explore the factors associated with elevated serum progesterone (P) levels on the day of hCG administration in patients undergoing controlled ovarian stimulation using a gonadotropin-releasing hormone antagonist (GnRH-A) protoco…

Adenomyosis and endometriosis are two sister diseases that cause menstrual pain and other symptoms. We have previously reported that patients with these conditions have a less active 'calm-and-rest' system and a more active 'stress-and-aler…

Apoptotic cells release a highly heterogeneous population of extracellular vesicles, which can be categorized into apoptotic bodies, apoptotic microvesicles, and apoptotic exosomes. These apoptotic vesicles (apoVs) not only inherit material…

BACKGROUND: Endometriosis (EMs) is a common gynecological disorder associated with impaired fertility and reduced quality of life. This study investigated abnormal spindle-like microcephaly-associated protein (ASPM), identified as a hub gen…

Ovarian response to controlled ovarian stimulation (COS) is a core determinant of assisted reproductive technology (ART) success, with marked interindividual variability. Accurate and individualized prediction is essential to optimize treat…

STUDY QUESTION: What is the current landscape of randomized controlled trials (RCTs) evaluating stem cell-based therapies for women's reproductive diseases, and how effectively has preclinical research informed their clinical translation? …

Primary aldosteronism (PA) is associated with a substantially higher cardiovascular risk than essential hypertension, a disparity that cannot be fully explained by blood pressure elevation alone. Clinical studies consistently demonstrate th…

BACKGROUND: Emerging evidence implicates the gut microbiota in the pathogenesis of adenomyosis (AM); however, whether this association is causal and through which mechanisms it operates remain largely unknown. METHODS: To interrogate poten…

Ovarian cancer remains a significant global health burden, with high-grade serous ovarian cancer (HGSOC) representing the most lethal subtype. Bulk RNA-seq analysis revealed KLK5 (Kallikrein-5, a serine protease) upregulation in ovarian can…

Mitochondrial dysfunction has been demonstrated with a role in pathologically driving various obstetric and gynecological (OB/GYN) diseases, but molecular mediators associating mitochondrial dysfunction with discrete pathologies have not be…

BACKGROUND: Ultrasound-based deep learning (DL) models for the precise diagnosis of endometrial cancer are insufficient. Our aim is to develop and validate an automatic multi-modal ultrasound DL prediction model for the accurate identificat…

BACKGROUND: Regional and hierarchical disparities in gynecological care may compromise equity and quality in China. Assessing structural resources, clinical processes, and outcomes is critical to guide system improvement. METHODS: We conduc…

Endometriosis is a prevalent gynecological disorder associated with chronic low-grade inflammation, yet diagnosis is often delayed because symptoms are non-specific and definitive confirmation typically relies on invasive procedures. Compos…

IntroductionSubinvolution of the postpartum uterus is a common puerperal complication. While Chinese herbal hot compress (CHHC) therapy has been widely applied to promote postpartum uterine involution, its underlying mechanisms remain uncle…

IntroductionAcupuncture has been explored as a potential intervention for POR; however, high-quality evidence is limited. This multicenter randomized trial evaluated the effect of acupuncture on the number of oocytes retrieved following con…

IntroductionDiminished ovarian reserve (DOR) is known to reduce the likelihood of achieving pregnancy or live births in women undergoing in vitro fertilization and embryo transfer (IVF-ET). Acupuncture maybe effective for DOR, but current e…

BackgroundEmbryo implantation failure and early pregnancy loss remain significant challenges in assisted reproductive technology (ART). Lipid peroxidation is known to be involved in reproductive physiology. However, its role during the impl…

BACKGROUND: Endometrial carcinoma arising from adenomyosis (EC-AIA) is remarkably uncommon, and its underlying molecular mechanisms are not yet fully elucidated. This knowledge gap is particularly significant given that most reported EC-AIA…

BACKGROUND: Endometriosis is a systemic gynecological disorder affecting ~ 10% of reproductive-aged women and shares pathophysiological features with cardiovascular disease (CVD). However, its associations with cardiac remodeling and CVD ri…

Extensive preclinical and clinical studies have shown that exposure to green light-emitting diodes (gLED) exerts analgesic effect. We hypothesized that exposure to gLED alleviates endometriosis-associated pain. To test this, we induced deep…

BackgroundOvarian cancer remains the most lethal gynecological cancer, with fewer than 50% of patients surviving more than 5 years after diagnosis. This study aimed to analyze the global epidemiological trends of ovarian cancer from 1990 to…

Interleukin-37 (IL-37) is an anti-inflammatory cytokine with an undefined role in chronic endometritis (CE). This study aims to explore its therapeutic mechanism in CE, focusing on epithelial-mesenchymal transition (EMT) and macrophage pola…

STUDY QUESTION: Does PIEZO1 play any role in adenomyosis-associated dysmenorrhea? SUMMARY ANSWER: PIEZO1 downregulation in the myometrium reduces the expression of endothelial nitric oxide synthase (eNOS) and nitric oxide (NO) production, …

BackgroundCervical squamous cell carcinoma (CSCC) exhibits profound spatial heterogeneity in evolutionary trajectories across distinct tumour foci, yet the underlying mechanisms remain poorly understood.MethodsIn this study, we performed an…