H Nagasawa

Like most characteristics studied in research, mammary tumourigenesis and uterine adenomyosis in mice are regulated by both genetic and environmental factors and information about the degree of participation of each factor in these lesions …

Some guanidino compounds have been found to inhibit spontaneous mammary tumourigenesis in mice. In the present study, the effects of chronic treatment with Gold Banded Lily (Lilium auratum LindI) or Chinese Milk Vetch (Astragalus sinicus L)…

We have found that the chronic administration of the diet containing 5% hydroxyapatite (HAP) derived from bovine or swine bone or drinking water containing 0.5% extract of coffee cherry (CC), the residue left after the removal of coffee bea…

Adenomyosis is a benign pathologic disorder of the uterine endometrial tissues whereby endometrial components, such as glands and stroma, invade the myometrium. Transplantation of a single anterior pituitary gland into the uterine lumen ind…

Virgin female SHN and SLN mice, a high and a low spontaneous mammary tumor strains, respectively, were given a single intravenous injection of streptozotocin (2 mg/10 g body weight), resulting in a significant rise of blood glucose levels a…

Buserelin, a potent LH-RH agonist, has been used for the treatment of hormonal disorders such as precocious puberty, endometriosis, cystic mastitis and prostatic carcinoma. Prolonged treatment with buserelin has been known to induce a refra…

The effects of traditional Chinese herbal remedies, Shakuyaku-kanzo-to (SKT) and Hachimijiou-gan (HJG), on the spontaneous development of uterine adenomyosis and mammary hyperplastic alveolar nodules (HAN) were examined in an experimental a…

Keishi-bukuryo-gan (KBG) is a traditional Chinese herbal remedy and has been used for the treatment of gynecological disorders, such as hypermenorrhea, dysmenorrhea, and infertility. The effects of KBG on the development of uterine adenomyo…

Subcutaneous implantation of a silastic tube containing the compound 4b, one of 2-(hydroxyphenyl) indoles, enhanced, while treatment with the compound diluted with cholesterol at the concentration of 1/40 inhibited the formation of preneopl…

(SLN × C3H/He)F1 virgin female mice showed higher incidences of spontaneous mammary tumours and uterine adenomyosis at advanced age than did the parental strains.

To evaluate further the chemopreventive role of motherwort (Leonurus sibiricus L; MW) in lesions of the mammary gland and uterus of GR/A mice, the effects on these lesions of the adsorbed (MW1) and unadsorbed (MW2) fractions of MW separated…

Ectopic pituitary isografts (EPI) have been found to induce a high incidence of uterine adenomyosis in SHN mice. All the SHN mice given EPI in the right uterus at 40 days of age developed uterine adenomyosis, and more than 80% of mice showe…

Development of uterine adenomyosis was examined in BALB/c mice. Anterior pituitary (AP) isografting at 8 weeks of age significantly increased the incidence of adenomyosis in mice by 36 weeks of age as compared to that in control mice bearin…

The development and the progression of uterine adenomyosis were compared with those of mammary tumours in four strains of mice with different mammary tumour potentials. Cumulative mammary tumour incidences were the highest and the lowest in…

The effects of lombricine extracted and purified from earthworm (Lumbricus terrestris) skin on the growth of palpable sizes (approximately 5 mm) of spontaneous mammary tumours were studied in SHN mice. In Experiment 1, daily subcutaneous in…

Chronic ingestion of methanol extract of the above-ground part of motherwort (Leonurus sibiricus L) in drinking water at the concentration of 0.5% enhanced the development of both pregnancy-dependent mammary tumours (PDMT) and mammary cance…

It has been shown in mice that progesterone stimulates both mammary tumourigenesis and uterine adenomyosis in intact animals in the presence of normal levels of prolactin and oestrogen. From the view-point of the high dependence of progeste…

The effects of single pituitary grafting and treatments with progesterone or oestrogen on mammary gland growth and uterine adenomyosis were studied in four strains of female and male mice with different mammary gland growth potentials (SHN/…

The effects of single pituitary grafting and treatments with progesterone or oestrogen on mammary gland growth and uterine adenomyosis were studied in four strains of female and male mice with different mammary gland growth potentials (SHN/…

Based on our previous findings that medroxyprogesterone acetate (MPA) significantly suppressed the formation of preneoplastic mammary hyperplastic alveolar nodules in mice, and that this suppression persisted for some time, we studied the e…

The relative incidence of mammary tumors with uterine adenomyosis was examined in SHN mice subjected to hormonal manipulation between 30 and 90 days of age. The incidence of mammary tumors paralleled that of adenomyosis in controls. A singl…