Streptozotocin-induced diabetes accelerates mammary tumorigenesis in shn and sln mice

Y Goto, H Nagasawa, T Iguchi
Oncology reports · 1995 · doi:10.3892/or.2.1.37 · PMID:21597684
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Streptozotocin-induced diabetes significantly increased mammary tumor incidence and accelerated tumor growth in SHN mice, but not SLN mice, indicating accelerated mammary tumorigenesis.

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This study examined whether streptozotocin-induced diabetes affects spontaneous mammary tumorigenesis in virgin female SHN and SLN mouse strains (high and low spontaneous mammary tumor background, respectively). Mice received a single intravenous streptozotocin injection, which significantly increased blood glucose levels and mammary tumor incidence; in SHN mice, tumor growth rate was also accelerated, whereas it was not in SLN mice. The authors reported that diabetes did not alter the incidence or progression of uterine adenomyosis and adenocarcinoma in either strain. This paper does not explicitly focus on endometriosis or adenomyosis, but it explicitly reports that adenomyosis was not affected by diabetes in SHN and SLN mice, providing relevance to adenomyosis.

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Abstract

Virgin female SHN and SLN mice, a high and a low spontaneous mammary tumor strains, respectively, were given a single intravenous injection of streptozotocin (2 mg/10 g body weight), resulting in a significant rise of blood glucose levels and of mammary tumor incidence. The growth rate of mammary tumors was also accelerated by streptozotocin-induced diabetes in SHN mice, but not in SLN mice. The incidence and progression of uterine adenomyosis and adenocarcinoma were not affected by diabetes in SHN and SLN mice. These findings indicate that spontaneous mammary tumorigenesis in SHN and SLN mice is accelerated by streptozotocin-induced diabetes.
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Print ISSN: 1021-335X Online ISSN: 1791-2431 International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease. International Journal of Oncology is an international journal devoted to oncology research and cancer treatment. Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery. Oncology Reports is an international journal devoted to fundamental and applied research in Oncology. Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine. Oncology Letters is an international journal devoted to Experimental and Clinical Oncology. Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology. International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis. Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology. Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition. Publishes open-access research on using epigenetics to advance understanding and treatment of human disease. An International Open Access Journal Devoted to General Medicine. Article - Authors: - Pages: 37-40|Published online on: January 1, 1995https://doi.org/10.3892/or.2.1.37 - Expand metrics + Virgin female SHN and SLN mice, a high and a low spontaneous mammary tumor strains, respectively, were given a single intravenous injection of streptozotocin (2 mg/10 g body weight), resulting in a significant rise of blood glucose levels and of mammary tumor incidence. The growth rate of mammary tumors was also accelerated by streptozotocin-induced diabetes in SHN mice, but not in SLN mice. The incidence and progression of uterine adenomyosis and adenocarcinoma were not affected by diabetes in SHN and SLN mice. These findings indicate that spontaneous mammary tumorigenesis in SHN and SLN mice is accelerated by streptozotocin-induced diabetes. Copy and paste a formatted citation Spandidos Publications style GOTO Y, NAGASAWA H and IGUCHI T: STREPTOZOTOCIN-INDUCED DIABETES ACCELERATES MAMMARY TUMORIGENESIS IN SHN AND SLN MICE. Oncol Rep 2: 37-40, 1995. APA GOTO, Y., NAGASAWA, H., & IGUCHI, T. (1995). STREPTOZOTOCIN-INDUCED DIABETES ACCELERATES MAMMARY TUMORIGENESIS IN SHN AND SLN MICE. Oncology Reports, 2, 37-40. https://doi.org/10.3892/or.2.1.37 MLA GOTO, Y., NAGASAWA, H., IGUCHI, T."STREPTOZOTOCIN-INDUCED DIABETES ACCELERATES MAMMARY TUMORIGENESIS IN SHN AND SLN MICE". Oncology Reports 2.1 (1995): 37-40. Chicago GOTO, Y., NAGASAWA, H., IGUCHI, T."STREPTOZOTOCIN-INDUCED DIABETES ACCELERATES MAMMARY TUMORIGENESIS IN SHN AND SLN MICE". Oncology Reports 2, no. 1 (1995): 37-40. https://doi.org/10.3892/or.2.1.37

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