Effects of different schedules of progesterone treatment on mammary tumorigenesis and uterine adenomyosis in SHN virgin mice

Hiroshi Nagasawa, H. Nagasawa, Nagasawa H, Aoki M, Makoto Aoki, M Aoki, Mori T, Takao Mori, T Mori
Life sciences · 1987 · vol. 40(26) , pp. 2597–2602 · doi:10.1016/0024-3205(87)90083-x · PMID:3600172 · W1987146717
article OA: closed CC0 ⤵ 2 in-corpus citations
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This study investigated the impact of varying progesterone treatment durations and intervals on the development of mammary tumors and uterine adenomyosis in virgin SHN mice.

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Abstract

As a possible step to estimate the factors controlling the effects of progesterone on mammary tumorigenesis, 3 groups of SHN virgin female mice were treated as follows beginning 2.5-4 months of age: Group A received the subcutaneous implantation of silastic tube containing progesterone (low dose) during the initial 4 months followed by progesterone pellet implantation (high dose) every 2 months. Group B was implanted with progesterone pellet throughout the experiment. Group C was given the vehicle only. Whereas there was little difference among groups in mammary tumorigenesis during the initial 4 months of treatments, tumorigenesis was significantly stimulated in group B thereafter. On the contrary, group A was different little from group C even after progesterone pellet implantation. The results indicate that the effects of progesterone on mammary tumorigenesis are affected by the 'preceding' progesterone conditions and that there is a critical period for manifestation of the effects of progesterone on mammary tumorigenesis, which is before 8 months of age at most. While all mice developing mammary tumors developed uterine adenomyosis in each group, the progression was enhanced by both low and high doses of progesterone.

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Condition tags

adenomyosis

MeSH descriptors

Mammary Neoplasms, Experimental Progesterone Uterine Diseases Animals Dose-Response Relationship, Drug Female Mammary Neoplasms, Experimental Mammary Neoplasms, Experimental Mice Mice, Inbred Strains Organ Size Organ Size Pituitary Gland, Anterior Pituitary Gland, Anterior Progesterone Uterine Diseases

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License: CC0 · commercial use OK