Effects of 2-(hydroxyphenyl) indole on mammary gland growth and uterine adenomyosis in four strains of mice.

Subcutaneous implantation of a silastic tube containing the compound 4b, one of 2-(hydroxyphenyl) indoles, enhanced, while treatment with the compound diluted with cholesterol at the concentration of 1/40 inhibited the formation of preneoplastic mammary hyperplastic alveolar nodules in four strains of mice (SHN/Mei, SLN/Mei, GR/AMei and C3H/HeMei). However, there was an apparent strain-difference in mammary susceptibility to 4b. Furthermore, the development of uterine adenomyosis in response to 4b varied from strain to strain. These results suggest that more attention should be paid to the choice of specific mouse strains for the study of related fields.