Lois A Salamonsen

Uniquely among adult tissues, the human endometrium undergoes cyclical shedding, scar-free repair and regeneration during a woman's reproductive life. Therefore, it presents an outstanding model for study of such processes. This Review exam…

The focus of my life in science has been to improve reproductive health for women, with an emphasis on the endometrium, the most dynamic tissue in the human body: its remarkable cyclical remodelling is essential for the establishment of pre…

Extensive evidence suggests that the release of membrane-enclosed compartments, more commonly known as extracellular vesicles (EVs), is a potent newly identified mechanism of cell-to-cell communication both in normal physiology and in patho…

Repair after damage is essential for tissue homeostasis. Postmenstrual endometrial repair is a cyclical manifestation of rapid, scar-free, tissue repair taking ∼3-5 d. Skin repair after wounding is slower (∼2 wk). In the case of chronic wou…

The human endometrium is a highly dynamic tissue that is cyclically shed, repaired, regenerated and remodelled, primarily under the orchestration of oestrogen and progesterone, in preparation for embryo implantation. Humans are among the ve…

Considerable correlative evidence suggests an important role for matrix metalloproteinases (MMPs) in menstruation, a pro-cess which occurs naturally in very few species. In this study, MMP expression was examined in a mouse model of endome-…

Menstruation is a complex process dependent on premenstrual release of inflammatory mediators and proteolytic enzymes from endometrial cells. Endometrial leukocytes are traditionally considered to be the major source of the inflammatory fac…

Menstruation involves the shedding of the functional layer of the endometrium in the absence of pregnancy. At sites where tissue shedding is complete, re-epithelialization of the tissue is essential for repair and termination of bleeding. T…

Proteomics techniques have been applied to identify proteins for development as diagnostic markers of endometriosis, but to date most studies have been unable to overcome the presence of highly abundant proteins. The main issues to be resol…

Repair of the postmenstrual endometrium presents a unique opportunity to examine nonscarring repair in an adult tissue. We aimed to characterize and determine the importance of extracellular matrix (ECM) dynamics in cell migration during en…

While the molecular mechanisms underlying endometrial destruction at menstruation are somewhat understood, the factors which govern post-menstrual repair remain somewhat of a mystery. The elegant electron micrograph work of Ludwig et al. ha…

BACKGROUND: During implantation, the embryo adheres to the endometrium via cell adhesion molecules (CAMs) present on blastocyst trophectoderm and endometrial epithelial cells. CAMs, including integrins and extracellular matrix (ECM) ligands…

BackgroundAlthough endometriosis is a common cause of pelvic pain and infertility, the pathogenesis of the disease remains poorly understood. Several theories have been proposed to explain the mechanisms involved in the development of this …

Background Although endometriosis is a common cause of pelvic pain and infertility, the pathogenesis of the disease remains poorly understood. Several theories have been proposed to explain the mechanisms involved in the development of this…

Introduction: Endometriosis, defined as the growth of endometrial tissue outside \nthe uterine cavity is a common gynaecological disorder affecting 10-15% \nof women in their reproductive years. It is a major clinical problem causing in- \n…

Endometriosis is a chronic disorder affecting approximately 10% of women in whom endometrial tissue forms painful lesions outside the uterus. It has a major impact on their physical, mental and social well-being but has no known cure, and t…

Over the past decade, high-throughput proteomics technologies have evolved considerably and have become increasingly more commonly applied to the investigation of female reproductive diseases. Proteomic approaches facilitate the identificat…

“The Curse,” the “Period,” “Riding the Crimson Wave,” “Aunt Flo,” and “the Red Coats are Coming” (euphemisms for menstrual bleeding) capture the long history of taboo and mystery of menstruation, a critical component of reproductive capabil…