Olivier Donnez

Endometriosis is one of the most frequently encountered benign diseases in gynecology. It is the cause of pelvic pain (dysmenorrhea, dyspareunia) and infertility in more than 35% of women of reproductive age [1]. Complete resolution of endo…

Endometriosis is one of the most frequent benign gynecological diseases and is known to occur in 7-10% of women of reproductive age. It is now well established that three different forms of endometriosis must be considered in the pelvis: pe…

OBJECTIVE: To study the occurrence of nerve fibers in deep nodular endometriotic lesions after nodules were induced in baboons and nerve fiber densities measured 6 months after the grafting procedure. DESIGN: Experimental animal study. SE…

Objective Detection of nerve fibers in endometrial biopsies was recently proposed as a noninvasive diagnostic tool for endometriosis. However, their occurrence in the functional layer of endometrium still remains controversial. Nerve fibers…

OBJECTIVE: To establish an experimental model for the study of deep nodular endometriosis. DESIGN: Induction of nodular endometriosis in baboons by grafting different uterine specimens to the peritoneal cavity. SETTING: Research and unive…

To define the role of surgery in the treatment of endometriomas, we review the literature available via PubMed and cross-reference the published data. We analyze the arguments in favor of and against surgical treatment of endometriomas and …

Endometriosis is one of the most frequently encountered benign diseases in gynecology. Complete resolution of endometriosis is not yet possible, but therapy has essentially three main objectives: (1) to preserve and improve fertility, (2) t…

Endometriosis is a chronic pelvic inflammatory process. Local inflammation is known to play a role in pain and infertility associated with the disease, and may be extensively involved in molecular and cellular processes leading to endometri…

OBJECTIVE: To determinethe prevalence of spontaneous endometriosis andthe incidence of induced endometriosis after endocervical canal resection in baboons. DESIGN: Induction and follow-up of endometriosis in baboons, which is one of the pr…

PURPOSE OF REVIEW: To evaluate different surgical options for the treatment of endometriomas. A heated debate is currently under way between advocates of excisional surgery and the ablative approach. With papers increasingly focusing on ova…

Peritoneal, ovarian, and rectovaginal endometriosis are three different entities. Peritoneal endometriosis can be explained by the transplantation theory. Coelomic metaplasia of invaginated epithelial inclusions may be responsible for the d…

OBJECTIVE: To describe and evaluate a new technique of laparoscopic treatment of endometriomas that combines excisional and ablative surgery. DESIGN: Descriptive and prospective study. SETTING: Gynecology research unit in a university hos…

OBJECTIVE: The aim of this study was to evaluate the complication rate after laparoscopic total hysterectomy and laparoscopic subtotal hysterectomy (LASH) in case of benign disease. DESIGN: All complications were prospectively recorded at …

STUDY OBJECTIVES: To analyze the prevalence of an unexpected complication due to morcellation and to describe the appearance of this complication on magnetic resonance imaging, as well as its therapy. DESIGN: A well-designed controlled tri…

Ovarian remnant syndrome is a rare but known complication of bilateral salpingo-oophorectomy associated or not with hysterectomy. This complication is frequently related to a history of multiple surgery, pelvic inflammatory disease, or endo…

OBJECTIVES: Cadmium (Cd) and lead (Pb) have been demonstrated to exert endocrine disrupting activities. Their possible role in endometriosis, an oestrogen-dependent disease, is unknown. METHODS: We compared cadmium urinary excretion (CdU) …

Peritoneal endometriosis (PE) and deep endometriotic nodules (DEN) are gynecological diseases recently shown to be associated with elevated serum concentrations of organochlorines. The objective of the present study was to compare risk fact…

We found, by reverse transcription--real time--polymerase chain reaction, that the expression of aromatase (CYP19) in ovarian, peritoneal endometriosis, and deep endometriotic nodules is significantly different, which strengthens the theory…

Five years after laparoscopic subtotal hysterectomy and morcellation, pelvic magnetic resonance imaging demonstrated the presence of an irregular and heterogeneous pelvic mass measuring 40 x 40 x 30 mm. Histologic examination confirmed smoo…

Dioxin-like compounds (DLCs) are suspected etiological factors of endometriosis but their potential mechanisms of action remain elusive. Because endometriosis is an estrogen-dependent disease and since aromatase (CYP19), a key enzyme in est…

Women with endometriosis typically present with pelvic pain, infertility or an adnexal mass. Surgery for persistent adnexal masses may be indicated to remove an endometrioma or other pelvic pathology. Surgical or medical therapy is efficaci…

The concept that peritoneal endometriosis, ovarian endometriosis and adenomyotic nodules of the rectovaginal septum are three different entities has been clearly demonstrated by Nisolle & Donnez in 1997. In other words, peritoneal and ovari…

In the pelvis, three different forms of endometriosis must be considered: 1) peritoneal endometriosis; 2) ovarian endometriosis and 3) rectovaginal septum endometriosis.