Sung Hoon Kim

The present study was designed to evaluate whether the expression of p21-activated kinase 1 (Pak1), which recently has been shown to be increased in the eutopic endometrium of women with endometriosis, is also increased in adenomyotic nodul…

Based on the findings of several reports that have shown an increased plasma level of di-(2-ethylhexyl) phthalate (DEHP) in women with endometriosis, the present study was designed to evaluate whether in vitro treatment with DEHP can increa…

Endometriosis is a long term, disabling condition and a relatively common disease, affecting 5~15% of the adult female population.

BACKGROUND: P21-activated kinase 1 (Pak1) integrates various signaling pathways that are vital to cell survival and function. This study was performed to evaluate whether sex steroids may regulate the expression of Pak1 in endometrial cells…

BACKGROUND: Altered expression of endothelial nitric oxide synthase (eNOS) has been reported to be involved in the development of endometriosis. The genotypes of eNOS gene (NOS3) may be responsible for variation in its enzymatic activity as…

PROBLEM: The intracellular antioxidant system, based on glutathione (GSH), plays a key role in endometrial detoxification reactions and has been proposed to be involved in the pathogenesis endometriosis. This study was designed to evaluate …

BACKGROUND: The purpose of this study was to investigate the potential association of the C627T polymorphism in the interleukin-2 receptor beta gene (IL-2R beta) with the risk of endometriosis in Korean women. METHODS: Two hundred and thir…

PURPOSE: Inflammatory cells can both suppress and stimulate tumor growth, and the influence of inflammatory cells on clinical outcome has been the focus of many studies. The purpose of this study was to evaluate the effectiveness of the neu…

BACKGROUND: Endometriosis is defined as the presence of endometrial tissue outside the uterus, causing diverse diseases, including infertility, pelvic pain, dysmenorrhea, and constipation. While there is a growing body of evidence that gene…

BACKGROUND: This study was performed to investigate whether specific haplotypes and several single nucleotide polymorphisms in the promoter region of the tumor necrosis factor (TNF)-alpha gene are associated with the risk of advanced stage …

Angiogenin, a potent inducer of angiogenesis, is expressed in human endometrium. This study was performed to compare the expression of angiogenin mRNA level in the eutopic endometrium from women with and without endometriosis. Thirty-two wo…

BACKGROUND: This study was performed to determine whether genetic polymorphisms of aryl hydrocarbon receptor repressor (AhRR), glutathione-S-transferase M1 (GSTM1) and glutathione-S-transferase T1 (GSTT1) are associated with susceptibility …

OBJECTIVE: To investigate whether the +1730 G/A polymorphism of the estrogen receptor beta (ER-beta) gene is associated with the risk of endometriosis in a Korean population. DESIGN: Case-control study. SETTING: University Department of O…

AIM: The objective of the present study was to compare the levels of expression of epidermal growth factor (EGF), fibroblast growth factor-2 (FGF-2), and platelet-derived growth factor-A (PDGF-A) mRNA in the eutopic endometrium of women wit…

Objective: This study was performed to investigate the expression of cathepsin B mRNA and Protein in eutopic and ectopic endometrial tissues of patients with endometriosis and in normal endometrial tissues, to compare the expression respect…

We report an unusual case in which a rapidly growing adenomyosis was identified during the first trimester in a 35-year-old infertile woman achieving pregnancy after controlled ovarian hyperstimulation. Relevant images are shown by magnetic…

Objective: This study was designed to investigate the association between C(-634)G polymorphism in the promotor region of vascualr endothelial growth factor (VEGF) and endometriosis. Methods: The genomic DNA was extracted from 100 patients …

The present study was designed to explore the association between estrogen receptor-alpha gene polymorphism and the risk of endometriosis by investigating the frequency of PvuII, XbaI, and thymine-adenine (TA) repeat polymorphisms in patien…

BACKGROUND: The aetiological factors of endometriosis still remain poorly understood. While there is growing evidence that genetic and immunological factors play important roles in the pathogenesis of the disease, HLA-DRB1 alleles have been…

Objective: To compare the expression of epidermal growth factor (EGF) and fibroblast growth factor-2 (FGF-2) in the eutopic endometrium of women with and without endometriosis. Methods: Thirty-two women with histologically confirmed endomet…

BACKGROUND: Vascular endothelial growth factor (VEGF) is known to play a pivotal role in the development of endometriosis. This study was performed to investigate whether the VEGF gene 5'-untranslated region polymorphism is associated with …

목적 : 본 연구는 자궁내막증 환자의 이소성 자궁내막과 정상 위치의 자궁내막 그리고, 자궁내막증이 없는 환자의 자궁내막에서 혈관내피성장인자 수용체 (vascular endothelial growth factor receptor, VEGFR) 의 발현정도를 비교하기 위하여 시행되었다. 연구 방법 : 양성 부인과 질환의 수술적 치료를 통하여, 자궁내막증으로 확인된 환자들을 실험군으로 하였으며, 자궁내막증이 없는 환자들을 대조군으…