Increased expression of p21-activated kinase in adenomyosis

So Ra Kim, Sung Hoon Kim, Hoi Woul Lee, Hee Dong Chae, Chung-Hoon Kim, Byung Moon Kang
Fertility and sterility · 2010 · doi:10.1016/j.fertnstert.2009.11.048 · PMID:20079895
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Abstract

The present study was designed to evaluate whether the expression of p21-activated kinase 1 (Pak1), which recently has been shown to be increased in the eutopic endometrium of women with endometriosis, is also increased in adenomyotic nodules as well as in the eutopic endometrium in women with adenomyosis. Comparative immunohistochemical study using a monoclonal antihuman Pak1 antibody revealed that the expression of Pak1 is increased in the eutopic endometrium of women with adenomyosis during the secretory phase, along with its increased expression in adenomyotic nodules, suggesting a possible role of Pak1 in the establishment of adenomyosis.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Endometriosis p21-Activated Kinases Uterine Diseases Adult Carcinoma in Situ Carcinoma in Situ Carcinoma in Situ Carcinoma in Situ Case-Control Studies Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Gene Expression Regulation, Enzymologic Humans Middle Aged p21-Activated Kinases

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europepmc
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