Increased viability of endometrial cells by in vitro treatment with di-(2-ethylhexyl) phthalate

Young-Hoon Kim, Young‐Hoon Kim, Kim YH, Kim SH, Sung Hoon Kim, Hoi Woul Lee, Lee HW, Hee Dong Chae, Chae HD, Kim CH, Chung-Hoon Kim, Chung‐Hoon Kim, Byung Moon Kang, Kang BM
Fertility and sterility · 2010 · vol. 94(6) , pp. 2413–2416 · doi:10.1016/j.fertnstert.2010.04.027 · PMID:20493477 · W2040838328
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study investigated the effect of di-(2-ethylhexyl) phthalate on endometrial cells and found that in vitro treatment increased their viability.

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Abstract

Based on the findings of several reports that have shown an increased plasma level of di-(2-ethylhexyl) phthalate (DEHP) in women with endometriosis, the present study was designed to evaluate whether in vitro treatment with DEHP can increase viability of endometrial cells. Utilizing 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide assay, fluorescent activated cell sorter analysis, and microscopic evaluation after Hoechst staining, we revealed that in vitro treatment with DEHP leads to increased viability of Ishikawa cells as well as endometrial stromal cells in serum-free condition and following exposure to hydrogen peroxide, which suggests that exposure to phthalate might play a role in the establishment of endometriosis.

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MeSH descriptors

Diethylhexyl Phthalate Endometrium Stromal Cells Cell Proliferation Cell Proliferation Cells, Cultured Cell Survival Cell Survival Diethylhexyl Phthalate Dose-Response Relationship, Drug Drug Evaluation, Preclinical Endometrium Endometrium Female Humans Plasticizers Plasticizers Stromal Cells Stromal Cells Time Factors

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