Yang Yang

OBJECTIVE: To apply an MR-PheWAS to infer causality between NSW and multiple health outcomes. METHODS: This study used MR-PheWAS to assess the causal effects of NSW on 18,115 health traits, applying IVW, MR-Egger, Wald ratio, and sensitivi…

BACKGROUND: Endometriosis is a debilitating gynaecological disorder with an elusive pathogenesis. While gut microbiota dysbiosis has been implicated, the causal role of gut-peritoneum microbial translocation and the specific mechanisms driv…

A considerable number of women of reproductive age suffer from endometriosis worldwide. There is a significant physical, mental, and financial burden on patients affected by this condition in terms of pelvic pain, either continuously or int…

Background: Endometriosis, characterized by extrauterine endometrial tissue, leads to irregular bleeding and pelvic pain. Menstrual retrograde theory suggests fragments traverse fallopian tubes, causing inflammation and scar tissue. Prevale…

Additional file 1: Table S1. Selected instrumental variables for coagulation factors in this study. Table S2. Summary statistics of the causal estimates of coagulation factors on endometriosis in UK Biobank. Table S3. The results of leave-o…

Additional file 1: Table S1. Selected instrumental variables for coagulation factors in this study. Table S2. Summary statistics of the causal estimates of coagulation factors on endometriosis in UK Biobank. Table S3. The results of leave-o…

Additional file 2: Fig. S1. Scatter plots for MR analyses of the causal effect of 11 coagulation factors on endometriosis in UK Biobank. Fig. S2. Plots of leave-one-out analyses for the causal associations in UK Biobank. Fig. S3. Scatter pl…

Additional file 2: Fig. S1. Scatter plots for MR analyses of the causal effect of 11 coagulation factors on endometriosis in UK Biobank. Fig. S2. Plots of leave-one-out analyses for the causal associations in UK Biobank. Fig. S3. Scatter pl…

PURPOSE: To establish a reliable nomogram model to predict the risk of major adverse pregnancy outcomes in pregnant women with adenomyosis, and to provide a reference tool for the hierarchical management and the prenatal examination of preg…

Abstract Background Endometriosis is recognized as a complex gynecological disorder that can cause severe pain and infertility, affecting 6–10% of all reproductive-aged women. Endometriosis is a condition in which endometrial tissue, which …

Abstract Background Endometriosis is recognized as a complex gynecological disorder that can cause severe pain and infertility, affecting 6–10% of all reproductive-aged women. Endometriosis is a condition in which endometrial tissue, which …

BACKGROUND: Endometriosis is recognized as a complex gynecological disorder that can cause severe pain and infertility, affecting 6-10% of all reproductive-aged women. Endometriosis is a condition in which endometrial tissue, which normally…

The processes underlying adenomyosis are similar to those of tumor metastasis, and it is defined as progressive invasion by the endometrium and the subsequent creation of ectopic lesions. GRIM-19 regulates cell death via the mitochondrial r…

Abstract Purpose To establish a reliable nomogram model to predict the risk of major adverse pregnancy outcomes in pregnant women with adenomyosis, and to provide a reference tool for the hierarchical management and the prenatal examinatio…

Although high-grade serous cancer (HGSC) accounts for >70% of ovarian epithelial cancers, it is rarely associated with endometriosis. No previous study has reported an association between the malignant transformation of uterine ligament end…

Research questionDoes the absence of GRIM19 affect pyroptosis of macrophages? Is the release of IL-1β caused by pyroptosis a relevant factor in the regulation of adenomyosis progression?DesignEndometrial tissues were collected from patients…

The epithelial-to-mesenchymal transition may play a role in adenomyosis. GRIM19 expression is downregulated in adenomyotic lesions, and the effects of this downregulation in adenomyosis remain relatively unclear. In this study, we aimed to …

Research questionDoes the aggregation of M2 macrophages affect the expression of gene associated with retinoid-interferon-induced mortality 19 (GRIM-19) in adenomyosis?DesignEndometrial tissues were collected from patients with (n = 15) and…

Podocyte apoptosis is considered as the important element that promotes the development and progress of membranous nephropathy (MN). Unfortunately, the underlying mechanism of podocytes apoptosis in MN remains elusive. We compared the renal…

OBJECTIVE: To study the expression of the gene associated with retinoid-interferon (IFN)-induced mortality 19 (GRIM-19) in the endometrial tissue of patients with adenomyosis and to describe the possible pathogenic mechanisms of this phenom…

Objective To investigate the role of phosphorylated-signal transduction and activator of transcription 3( p-STAT3)( Y705) and vascular endothelial growth factor( VEGF) in the development of adenomyosis by detecting the expression of p-STAT3…

Ethnopharmacological relevanceFerulic acid (FA), ligustrazine (LZ) and tetrahydropalmatine (THP) are separately isolated from Chinese Angelica, Szechwan Lovage Rhizome and Rhizoma in the Jiawei-Foshou-San formula, a popular traditional Chin…

Objective:To study the effect of estrogen on anovulatory dysfunctional uterine bleeding(ADUB).Methods:Primary endometrial epithelial cells of Hainan Lizu female was cultured and hydrolylic activity of gelalinase was determined by gelatin zy…

Objective To explore the effect of gynecological laparoscopy on the blood coagulation and it's relation with variable expression level of the plasma alpha-granule mambrane protein 140(GMP-140),D-dimer,and von willebrand factor(VWF).Methods …