Transcription factor addictions: exploring the potential Achilles' Heel of endometriosis

A considerable number of women of reproductive age suffer from endometriosis worldwide. There is a significant physical, mental, and financial burden on patients affected by this condition in terms of pelvic pain, either continuously or intermittently, dysmenorrhea, infertility, and a higher risk of certain types of cancer. Several treatments available in clinical settings for endometriosis management do not provide adequate efficacy and have undesirable side effects. Transcription factors (TFs) are crucial regulators of key biological processes involved in endometriosis. Here, we elaborated on the research progress regarding the crucial roles of TFs in endometriosis, emphasizing their implications for clinical outcomes and critical therapeutic contributions. By delving into their involvement in key processes, such as cell proliferation and apoptosis, we revealed the multifaceted role of key TFs in disease progression. We aimed to provide a systemic understanding of TFs regulation in endometriosis pathogenesis, establishing a foundation for innovative treatment approaches. Similar content being viewed by others

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This work was supported by the National Key Research and Development Program of China (2022YFA1106600), the National Natural Science Foundation of China (82325039, 82273255, 81822034, 81821002), and Sichuan Province Science and Technology Program (2022NSFSC1340). Author information Authors and Affiliations Corresponding authors Ethics declarations The authors declare that they have no conflict of interest. Rights and permissions About this article Cite this article Yang, Y., Du, Y., Ma, X. et al. Transcription factor addictions: exploring the potential Achilles’ Heel of endometriosis. Sci. China Life Sci. 68, 2277–2289 (2025). https://doi.org/10.1007/s11427-024-2832-8 Received: Accepted: Published: Version of record: Issue date: DOI: https://doi.org/10.1007/s11427-024-2832-8