Burkhard Greve

No ORCID on file · 14 papers in corpus · active 2012-2025

Study types

  • article 11
  • other 1
  • preprint 1
  • review 1

Condition tags

  • endometriosis 11
  • mesh:D004715 7
  • infertility 1
  • die_deep_infiltrating 1
article 2025
Combined targeting of TCF7L1 /2, PTEN , CDK6 , and BCCIP by microRNA miR ‐29c‐3p is associated with reduced invasion and proliferation of endometriotic cells
Reproductive medicine and biology ·doi:10.1002/rmb2.12645

Abstract Purpose Endometriosis is a chronic gynecological disorder associated with pain symptoms and infertility. The expression of microRNA miR‐29c‐3p is dysregulated in endometriosis. We aimed to identify novel molecular targets of miR‐29…

review 2023
The Musashi RNA-binding proteins in female cancers: insights on molecular mechanisms and therapeutic relevance
Biomarker research ·doi:10.1186/s40364-023-00516-2

RNA-binding proteins have increasingly been identified as important regulators of gene expression given their ability to bind distinct RNA sequences and regulate their fate. Mounting evidence suggests that RNA-binding proteins are involved …

article 2022
Impact of Musashi-1 and Musashi-2 Double Knockdown on Notch Signaling and the Pathogenesis of Endometriosis
International journal of molecular sciences ·doi:10.3390/ijms23052851

The stem cell marker and RNA-binding protein Musashi-1 is overexpressed in endometriosis. Musashi-1-siRNA knockdown in Ishikawa cells altered the expression of stem cell related genes, such as OCT-4. To investigate the role of both human Mu…

article 2022
Resveratrol impairs cellular mechanisms associated with the pathogenesis of endometriosis
Reproductive biomedicine online ·doi:10.1016/j.rbmo.2022.02.008
article 2021
Collagen I triggers directional migration, invasion and matrix remodeling of stroma cells in a 3D spheroid model of endometriosis
Scientific reports ·doi:10.1038/s41598-021-83645-8

Endometriosis is a painful gynecological condition characterized by ectopic growth of endometrial cells. Little is known about its pathogenesis, which is partially due to a lack of suitable experimental models. Here, we use endometrial stro…

article 2021
The ellagic acid metabolites urolithin A and B differentially affect growth, adhesion, motility, and invasion of endometriotic cells in vitro
Human Reproduction ·doi:10.1093/humrep/deab053

Abstract STUDY QUESTION What are the effects of plant-derived antioxidant compounds urolithin A (UA) and B (UB) on the growth and pathogenetic properties of an in vitro endometriosis model? SUMMARY ANSWER Both urolithins showed inhibitory e…

preprint 2020
The scar constituent Collagen I triggers coordinated collective migration and invasion in a 3D spheroid model of early endometriotic lesions
·doi:10.1101/2020.04.02.005322

Abstract Endometriosis is a painful gynaecological condition characterized by ectopic growth of endometrial cells outside of the uterus. Little is known about the mechanisms by which endometrial fragments invade tissues. This is partially d…

article 2019
γ‐Secretase inhibition affects viability, apoptosis, and the stem cell phenotype of endometriotic cells
Acta obstetricia et gynecologica Scandinavica ·doi:10.1111/aogs.13707

INTRODUCTION: Stem cells mediate cyclic regeneration of the endometrium. The upregulated expression of receptors and modulators of the notch signaling pathway in endometriosis suggests an involvement in the pathogenetic process. Here, we in…

article 2016
microRNA miR-200b affects proliferation, invasiveness and stemness of endometriotic cells by targeting ZEB1, ZEB2 and KLF4
Reproductive biomedicine online ·doi:10.1016/j.rbmo.2015.12.013
article 2014
microRNA miR-200b differentially affects proliferation, invasiveness and stemness of endometriotic cells by targeting the transcription factors KLF4, ZEB1 and ZEB2
·doi:10.1055/s-0034-1371993

Introduction: Endometriosis is a hormone-dependent disease characterized by growth of endometrial tissue at ectopic locations. Recent results indicate a dysregulation of microRNAs, small non-coding posttransciprional regulators of gene expr…

other 2013
MicroRNA miR-145 inhibits proliferation, invasiveness, and stem cell phenotype of an in vitro endometriosis model by targeting multiple cytoskeletal elements and pluripotency factors
Fertility and sterility ·doi:10.1016/j.fertnstert.2012.11.055

OBJECTIVE: To study the function of miR-145, known to be dysregulated in endometriosis, and to identify its target genes in an in vitro endometriosis model. DESIGN: Experimental laboratory study. SETTING: University medical centers. PATI…

article 2013
Pharmacological interference with the stemness-associated Notch-signaling pathway exerts an antiproliferative effect on the endometriotic 12Z cell line
·doi:10.1055/s-0033-1336720

Adult stem cells are thought to participate in endometrial regeneration during the reproductive phase of women. We have previously demonstrated dysregulated stem cell activity in endometriosis, a benign disease associated with unspecific pa…

article 2013
Targeting of Syndecan-1 by microRNA miR-10b modulates invasiveness of endometriotic cells via dysregulation of IL-6 secretion and MAPK signaling
·doi:10.1055/s-0033-1336719

microRNAs are small non-coding RNAs which regulate gene expression at the posttranscriptional and translational level. microRNAs have previously been demonstrated to be dysregulated in endometriosis, a hormone-dependent disease associated w…

article 2012
Targeting of syndecan-1 by micro-ribonucleic acid miR-10b modulates invasiveness of endometriotic cells via dysregulation of the proteolytic milieu and interleukin-6 secretion
Fertility and sterility ·doi:10.1016/j.fertnstert.2012.10.051