Osamu Takaoka

No ORCID on file · 13 papers in corpus · active 2015-2025

Study types

  • article 11
  • other 1
  • review 1

Condition tags

  • endometriosis 13
  • mesh:D004715 9
  • endometrioma 4
  • die_deep_infiltrating 1
other 2025
Daidzein-rich isoflavone aglycones inhibit 17β-hydroxysteroid dehydrogenase 1 and increase estrogen sulfotransferase in endometriosis
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology ·doi:10.1080/09513590.2025.2516202

OBJECTIVE: Endometriosis is an estrogen-dependent disease wherein isoflavones interact with estrogen receptors. Daidzein-rich isoflavone aglycones (DRIAs) have been shown to inhibit cell proliferation and aromatase activity in vitro and in …

article 2023
Hepcidin as a key regulator of iron homeostasis triggers inflammatory features in the normal endometrium
Free radical biology & medicine ·doi:10.1016/j.freeradbiomed.2023.10.402

Menstrual blood, containing high iron levels, can undergo retrograde transport into the abdominal cavity. Excess iron causes oxidative stress and inflammation. Iron metabolism is regulated by hepcidin, and serum hepcidin levels are increase…

article 2022
Low-Nutrient Environment-Induced Changes in Inflammation, Cell Proliferation, and PGC-1α Expression in Stromal Cells with Ovarian Endometriosis
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1007/s43032-022-01089-5
review 2019
Local estrogen formation and its regulation in endometriosis
Reproductive medicine and biology ·doi:10.1002/rmb2.12285

BACKGROUND: It has been well established that endometriosis is an estrogen-dependent disease. Although the exact pathogenesis of the disease is still unclear, it is known to be characterized by estrogen-dependent growth and maintenance of t…

article 2018
Daidzein-rich isoflavone aglycones inhibit cell growth and inflammation in endometriosis
The Journal of steroid biochemistry and molecular biology ·doi:10.1016/j.jsbmb.2018.04.004
article 2018
Dienogest therapy during the early stages of recurrence of endometrioma might be an alternative therapeutic option to avoid repeat surgeries
Journal of Obstetrics and Gynaecology Research ·doi:10.1111/jog.13725

AIM: We aimed to evaluate whether hormonal therapy immediately after postsurgical recurrence of ovarian endometrioma controls disease progression and can be an alternative therapeutic option to avoid multiple repeat surgeries. METHODS: We e…

article 2017
Exacerbation of Endometriosis Due To Regulatory T-Cell Dysfunction
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2017-00052

Context: Endometriosis is a chronic inflammatory disease associated with altered immune response to endometrial cells facilitating the implantation and proliferation of ectopic endometrial tissues. Although regulatory T (Treg) cells play a …

article 2016
Enlarged uterine corpus volume in women with endometriosis: Assessment using three‐dimensional reconstruction of pelvic magnetic resonance images
Journal of Obstetrics and Gynaecology Research ·doi:10.1111/jog.13153

AIM: To assess and compare the uterine volume and endometrium length between women with and without endometriosis, using pelvic magnetic resonance imaging scans. METHODS: In this case-control study, a total of 75 nulligravid women (aged 20-…

article 2016
Impairment of Treg's immune regulation in endometriosis
·doi:10.1016/j.jri.2016.10.055
article 2016
IS-AC-5-2 Exacerbation of endometriosis by dysfunction of regulatory T cells in mouse and human(Group 5 Reproduction/Women's Health,International Session Award Candidate) :
article 2016
ISP-31-7 Enlarged uterine corpus volume in women with endometriosis : assessment using three-dimensional reconstruction of pelvic magnetic resonance images(Group 31 Endometriosis,International Session Poster)
article 2015
Dienogest reduces HSD17β1 expression and activity in endometriosis
The Journal of endocrinology ·doi:10.1530/joe-15-0052

Endometriosis is an estrogen-dependent disease. Abnormally biosynthesized estrogens in endometriotic tissues induce the growth of the lesion and worsen endometriosis-associated pelvic pain. Dienogest (DNG), a selective progesterone receptor…

article 2015
G protein–coupled estrogen receptor 1 agonist G-1 induces cell cycle arrest in the mitotic phase, leading to apoptosis in endometriosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2015.01.026