Miwako Nagai

No ORCID on file · 12 papers in corpus · active 2012-2017

Study types

  • article 11
  • other 1

Condition tags

  • endometriosis 11
  • endometrioma 6
other 2017
Mannose receptor is highly expressed by peritoneal dendritic cells in endometriosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2016.09.036

OBJECTIVES: To characterize peritoneal dendritic cells (DCs) in endometriosis and to clarify their role in its etiology. DESIGN: Experimental. SETTING: University hospital. PATIENT(S): Sixty-three women (35 patients with endometriosis an…

article 2016
Effects of 1,25-Dihydroxy Vitamin D3 on Endometriosis
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2016-1515

CONTEXT: Endometriosis is an estrogen-dependent, chronic inflammatory disease. Recent studies have shown that vitamin D (VD) is an effective modulator of the immune system and plays an important role in controlling many inflammatory disease…

article 2016
Neutrophil depletion reduces endometriotic lesion formation in mice
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/aji.12540

PROBLEM: Neutrophils are known to be accumulated in endometriosis; however, direct evidence of the impact of neutrophils in the development of endometriosis was lacking. To clarify the importance of neutrophils, we examined the effect of ne…

article 2015
ISP-9-7 The vitamin D status in endometriosis(Group 9 Reproduction 1,IS Poster,International Session)
article 2015
The vitamin D status in endometriosis
article 2014
Dienogest reduces proliferation, aromatase expression and angiogenesis, and increases apoptosis in human endometriosis
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology ·doi:10.3109/09513590.2014.911279

Dienogest is a novel progestin that is highly selective for progesterone receptors and inhibits endometriosis. However, it remains unknown how the administration of dienogest to patients with endometriosis impacts on their lesion tissues. T…

article 2014
IL-1β Increases Expression of Tryptophan 2,3-dioxygenase and Stimulates Tryptophan Catabolism in Endometrioma Stromal Cells
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/aji.12282

PROBLEM: Immune tolerance to endometriotic cells is important to promote endometriosis. Tryptophan 2,3-dioxygenase (TDO) enhances immune tolerance by catabolizing tryptophan to kynurenine. We studied whether interleukin-1β (IL-1β), a typica…

article 2014
The serum level of vitamin D of endometriosis patients
·doi:10.1016/j.jri.2014.09.050
article 2013
Interleukin-4 and Prostaglandin E2 Synergistically Up-Regulate 3β-Hydroxysteroid Dehydrogenase Type 2 in Endometrioma Stromal Cells
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2012-3475

CONTEXT: Endometriosis is a chronic inflammatory disease in which immune response and production of estrogen in endometriotic tissues are involved in the development of the disease. Prostaglandin E2 (PGE2) stimulates aromatase (P450arom) ex…

article 2013
ISO-3-1 Interleukin (IL)-4 and prostaglandin (PG) E2 synergistically increase the expression of 3β hydroxysteroid dehydrogenase type 2 (HSD3B2) in endometrioma stromal cells(Group 3 Reproduction/Women's Health,IS Award Candidate,International Session)
article 2012
Interleukin-1β stimulates the secretion of thymic stromal lymphopoietin (TSLP) from endometrioma stromal cells: possible involvement of TSLP in endometriosis
Human Reproduction ·doi:10.1093/humrep/des291

STUDY QUESTION: Is thymic stromal lymphopoietin (TSLP) involved in the pathophysiology of endometriosis? SUMMARY ANSWER: TSLP is up-regulated by interleukin (IL)-1β and may be involved in the development of endometriosis. WHAT IS KNOWN ALRE…

article 2012
Peritoneal dendrtic cells phagocyte retrograde menstrual endometrial cells and contribute to the progress of endometriosis
·doi:10.1016/j.jri.2012.03.392